Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of
stroke, heart failure, and death,. Fourteen genetic loci have been associated with atrial …
stroke, heart failure, and death,. Fourteen genetic loci have been associated with atrial …
Multi-ethnic genome-wide association study for atrial fibrillation
Atrial fibrillation (AF) affects more than 33 million individuals worldwide and has a complex
heritability. We conducted the largest meta-analysis of genome-wide association studies …
heritability. We conducted the largest meta-analysis of genome-wide association studies …
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
PT Ellinor, KL Lunetta, CM Albert, NL Glazer… - Nature …, 2012 - nature.com
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart
failure and death. We conducted a genome-wide association study (GWAS) in individuals of …
failure and death. We conducted a genome-wide association study (GWAS) in individuals of …
Genetics of atrial fibrillation in 2020: GWAS, genome sequencing, polygenic risk, and beyond
Atrial fibrillation is a common heart rhythm disorder that leads to an increased risk for stroke
and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic …
and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic …
[PDF][PDF] Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development
Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart
failure, and premature death. The pathogenesis of AF remains poorly understood, which …
failure, and premature death. The pathogenesis of AF remains poorly understood, which …
Genome-wide association studies of atrial fibrillation: past, present, and future
Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three
distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the …
distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the …
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology
To identify genetic variation underlying atrial fibrillation, the most common cardiac
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …
Common variation in atrial fibrillation: navigating the path from genetic association to mechanism
Atrial fibrillation (AF) is the most common cardiac arrhythmia with well-established clinical
and genetic risk components. Genome-wide association studies (GWAS) have identified 17 …
and genetic risk components. Genome-wide association studies (GWAS) have identified 17 …
Genetic control of left atrial gene expression yields insights into the genetic susceptibility for atrial fibrillation
J Hsu, S Gore-Panter, G Tchou, L Castel… - Circulation: Genomic …, 2018 - Am Heart Assoc
Background: Genome-wide association studies have identified 23 loci for atrial fibrillation
(AF), but the mechanisms responsible for these associations, as well as the causal genes …
(AF), but the mechanisms responsible for these associations, as well as the causal genes …
Integrative omics approach to identifying genes associated with atrial fibrillation
Rationale: GWAS (Genome-Wide Association Studies) have identified hundreds of genetic
loci associated with atrial fibrillation (AF). However, these loci explain only a small …
loci associated with atrial fibrillation (AF). However, these loci explain only a small …
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