Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

IE Christophersen, M Rienstra, C Roselli, X Yin… - Nature …, 2017 - nature.com
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of
stroke, heart failure, and death,. Fourteen genetic loci have been associated with atrial …

Multi-ethnic genome-wide association study for atrial fibrillation

C Roselli, MD Chaffin, LC Weng, S Aeschbacher… - Nature …, 2018 - nature.com
Atrial fibrillation (AF) affects more than 33 million individuals worldwide and has a complex
heritability. We conducted the largest meta-analysis of genome-wide association studies …

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

PT Ellinor, KL Lunetta, CM Albert, NL Glazer… - Nature …, 2012 - nature.com
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart
failure and death. We conducted a genome-wide association study (GWAS) in individuals of …

Genetics of atrial fibrillation in 2020: GWAS, genome sequencing, polygenic risk, and beyond

C Roselli, M Rienstra, PT Ellinor - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation is a common heart rhythm disorder that leads to an increased risk for stroke
and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic …

[PDF][PDF] Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development

JB Nielsen, LG Fritsche, W Zhou, TM Teslovich… - The American Journal of …, 2018 - cell.com
Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart
failure, and premature death. The pathogenesis of AF remains poorly understood, which …

Genome-wide association studies of atrial fibrillation: past, present, and future

MF Sinner, PT Ellinor, T Meitinger… - Cardiovascular …, 2011 - academic.oup.com
Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three
distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the …

Biobank-driven genomic discovery yields new insight into atrial fibrillation biology

JB Nielsen, RB Thorolfsdottir, LG Fritsche, W Zhou… - Nature …, 2018 - nature.com
To identify genetic variation underlying atrial fibrillation, the most common cardiac
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …

Common variation in atrial fibrillation: navigating the path from genetic association to mechanism

NR Tucker, S Clauss, PT Ellinor - Cardiovascular research, 2016 - academic.oup.com
Atrial fibrillation (AF) is the most common cardiac arrhythmia with well-established clinical
and genetic risk components. Genome-wide association studies (GWAS) have identified 17 …

Genetic control of left atrial gene expression yields insights into the genetic susceptibility for atrial fibrillation

J Hsu, S Gore-Panter, G Tchou, L Castel… - Circulation: Genomic …, 2018 - Am Heart Assoc
Background: Genome-wide association studies have identified 23 loci for atrial fibrillation
(AF), but the mechanisms responsible for these associations, as well as the causal genes …

Integrative omics approach to identifying genes associated with atrial fibrillation

B Wang, KL Lunetta, J Dupuis, SA Lubitz… - Circulation …, 2020 - Am Heart Assoc
Rationale: GWAS (Genome-Wide Association Studies) have identified hundreds of genetic
loci associated with atrial fibrillation (AF). However, these loci explain only a small …