Medicines from nature: are natural products still relevant to drug discovery?
AL Harvey - Trends in Pharmacological Sciences, 1999 - cell.com
Historically, most drugs have been derived from natural products, but there has been a shift
away from their use with the increasing predominance of molecular approaches to drug …
away from their use with the increasing predominance of molecular approaches to drug …
Natural products in drug discovery: present status and perspectives
G Molinari - Pharmaceutical Biotechnology, 2009 - Springer
Natural products and their derivatives have been and continue to be rich sources for drug
discovery. However, natural products are not drugs. They are produce in nature and through …
discovery. However, natural products are not drugs. They are produce in nature and through …
Natural products in drug discovery: impacts and opportunities—an assessment
G Brahmachari - … natural products: opportunities and challenges in …, 2012 - World Scientific
Nature stands as an inexhaustible source of novel chemotypes and pharmacophores, and
has been a source of medicinal agents for thousands of years, and an impressive number of …
has been a source of medicinal agents for thousands of years, and an impressive number of …
[HTML][HTML] The success of natural products in drug discovery
M Lahlou - 2013 - scirp.org
Drug discovery leading to robust and viable lead candidates' remains a challenging
scientific task, which is the transition from a screening hit to a drug candidate, requires …
scientific task, which is the transition from a screening hit to a drug candidate, requires …
The evolving role of natural products in drug discovery
FE Koehn, GT Carter - Nature reviews Drug discovery, 2005 - nature.com
Natural products and their derivatives have historically been invaluable as a source of
therapeutic agents. However, in the past decade, research into natural products in the …
therapeutic agents. However, in the past decade, research into natural products in the …
[PDF][PDF] Recent natural products based drug development: a pharmaceutical industry perspective
YZ Shu - Journal of natural products, 1998 - chem.uwec.edu
The search for new pharmacologically active agents obtained by screening natural sources
such as microbial fermentations and plant extracts has led to the discovery of many clinically …
such as microbial fermentations and plant extracts has led to the discovery of many clinically …
Natural products in drug discovery–creating a new vision
GA Cordell - Phytochemistry Reviews, 2002 - Springer
Abstract “If only they had chosen to develop natural product drugs in a sustainable manner
at the turn of the century”. In 2050, when the Earth has a population of at least 9 billion, will …
at the turn of the century”. In 2050, when the Earth has a population of at least 9 billion, will …
The role of natural product chemistry in drug discovery
MS Butler - Journal of natural products, 2004 - ACS Publications
Although traditionally natural products have played an important role in drug discovery, in
the past few years most Big Pharma companies have either terminated or considerably …
the past few years most Big Pharma companies have either terminated or considerably …
Natural products as a resource for new drugs
AM Clark - Pharmaceutical research, 1996 - Springer
Natural products have served as a major source of drugs for centuries, and about half of the
pharmaceuticals in use today are derived from natural products. The aim of this review is to …
pharmaceuticals in use today are derived from natural products. The aim of this review is to …
[PDF][PDF] Role of natural products in drug discovery process
Natural products and their related moieties have historically been incredible as a source of
therapeutic agents. In last 5-10 years, research into natural products in the pharmaceutical …
therapeutic agents. In last 5-10 years, research into natural products in the pharmaceutical …