Neuropsychiatric systemic lupus erythematosus (NPSLE) has a broad spectrum of subtypes
with diverse severities and prognoses. Ischemic and inflammatory mechanisms, including …

The role of complement activation in the brains of MRL/lpr lupus mice was determined using
the potent C3 convertase inhibitor, CR1-related y (Crry), administered both as an …

Oxidative stress critically contributes to the pathogenesis of a variety of neurodegenerative
diseases such as multiple sclerosis. Astrocytes are the main regulators of oxidative …

Timely clearance of myelin debris is the premise of neuroinflammation termination and
tissue regeneration in multiple sclerosis (MS). Microglia are the main scavengers of myelin …

Summary Complement receptor 3 (CR3) activation in microglia is involved in
neuroinflammation-related brain disorders and pruning of neuronal synapses. Hypoxia …

Mouse models of autoimmunity, such as (NZB× NZW) F1, MRL/MpJ-Fas lpr (MRL-lpr) and
BXSB mice, spontaneously develop systemic lupus erythematosus (SLE)-like syndromes …

Microglia and other tissue-resident macrophages within the central nervous system (CNS)
have essential roles in neural development, inflammation and homeostasis. However, the …

The triggering of innate immune mechanisms is emerging as a crucial component of major
neurodegenerative diseases. Microglia and other cell types in the brain can be activated in …

Parkinson's disease (PD) is mainly characterized by the progressive degeneration of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) and neuroinflammation …

Abnormal NFκB activation has been implicated in Alzheimer's disease (AD). However, the
signaling pathways governing NFκB regulation and function in the brain are poorly …