Strong evidence implicates the complement pathway as an important contributor to amyloid
pathology in Alzheimer's disease (AD); however, the role of complement in tau modulation …

Microglial NADPH oxidase (Nox2) plays a key role in chronic neuroinflammation and related
dopaminergic neurodegeneration in Parkinson's disease (PD). However, the mechanisms …

Background The neuronal ceroid lipofuscinoses (CLN diseases) are fatal lysosomal storage
diseases causing neurodegeneration in the CNS. We have previously shown that …

Neuropsychiatric lupus (NPSLE) is a debilitating manifestation of SLE which occurs in a
majority of SLE patients and has a variety of clinical manifestations. In the central nervous …

The pathology of Parkinson's disease (PD) is characterized by α-synuclein aggregation,
microglia-mediated neuroinflammation, and dopaminergic neurodegeneration in the …

Given the early onset of neuropsychiatric disease and the potential response to
immunosuppressive therapy, neuropsychiatric disease is considered a primary disease …

Microglia-mediated neuroinflammation is involved in various neurological diseases,
including ischemic stroke, but the endogenous mechanisms preventing unstrained …

Nuclear receptor4 group A1 (Nr4a1), an orphan nuclear receptor, is down-regulated in
peripheral blood mononuclear cells (MNCs) of individuals with multiple sclerosis (MS), and …

Gliogenesis under pathophysiological conditions is of particular clinical relevance since it
may provide evidence for regeneration promoting cells recruitable for therapeutic purposes …

Microglial NLRP3 inflammasome activation is emerging as a key contributor to
neuroinflammation during neurodegeneration. Pathogenic protein aggregates such as β …