NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes
Inflammation in the brain accompanies several high-impact neurological diseases including
multiple sclerosis (MS), stroke, and Alzheimer's disease. Neuroinflammation is sterile, as …
multiple sclerosis (MS), stroke, and Alzheimer's disease. Neuroinflammation is sterile, as …
[HTML][HTML] Unique primed status of microglia under the systemic autoimmune condition of lupus-prone mice
A Nomura, D Noto, G Murayama, A Chiba… - Arthritis Research & …, 2019 - Springer
Background Systemic lupus erythematosus (SLE) is an autoimmune disease characterized
by the production of various autoantibodies. This disease causes disabling neuropsychiatric …
by the production of various autoantibodies. This disease causes disabling neuropsychiatric …
C3aR inhibition reduces neurodegeneration in experimental lupus
Complement activation is an important aspect of systemic lupus erythematosus. In this study
we investigated the role of C3a/C3a receptor (R) signaling in brains of the lupus model …
we investigated the role of C3a/C3a receptor (R) signaling in brains of the lupus model …
Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome
Alzheimer's disease is the most prevalent type of dementia and is caused by the deposition
of extracellular amyloid‐beta and abnormal tau phosphorylation. Neuroinflammation has …
of extracellular amyloid‐beta and abnormal tau phosphorylation. Neuroinflammation has …
Neuroprotective versus neuroinflammatory roles of complement: from development to disease
M Kanmogne, RS Klein - Trends in neurosciences, 2021 - cell.com
Complement proteins are ancient components of innate immunity that have emerged as
crucial regulators of neural networks. We discuss these roles in the context of the CNS …
crucial regulators of neural networks. We discuss these roles in the context of the CNS …
C5a/CD88 signaling alters blood–brain barrier integrity in lupus through nuclear factor‐κB
A Jacob, B Hack, P Chen, RJ Quigg… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 119, 1041–1051. Abstract Inflammation is a key factor in a number of
neurodegenerative diseases including systemic lupus erythematosus. The complement …
neurodegenerative diseases including systemic lupus erythematosus. The complement …
[HTML][HTML] Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex
Background Cognitive impairment in schizophrenia, aging, and Alzheimer's disease is
associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer …
associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer …
Zinc status alters Alzheimer's disease progression through NLRP3-dependent inflammation
J Rivers-Auty, VS Tapia, CS White… - Journal of …, 2021 - Soc Neuroscience
Alzheimer's disease is a devastating neurodegenerative disease with a dramatically
increasing prevalence and no disease-modifying treatment. Inflammatory lifestyle factors …
increasing prevalence and no disease-modifying treatment. Inflammatory lifestyle factors …
[HTML][HTML] Heterozygous CX3CR1 deficiency in microglia restores neuronal β-amyloid clearance pathways and slows progression of Alzheimer's like-disease in PS1 …
SE Hickman, EK Allison, U Coleman… - Frontiers in …, 2019 - frontiersin.org
CX3CR1 is a chemokine receptor expressed on microglia that binds Fractalkine (CX3CL1)
and regulates microglial recruitment to sites of neuroinflammation. Full deletion of CX3CR1 …
and regulates microglial recruitment to sites of neuroinflammation. Full deletion of CX3CR1 …
[HTML][HTML] Targeting microglial and neuronal toll-like receptor 2 in synucleinopathies
Synucleinopathies are neurodegenerative disorders characterized by the progressive
accumulation of α-synuclein (α-syn) in neurons and glia and include Parkinson's disease …
accumulation of α-synuclein (α-syn) in neurons and glia and include Parkinson's disease …