Parkinson's disease (PD) is characterized by a profound loss of dopaminergic neurons in
the substantia nigra, accompanied by chronic neuroinflammation, mitochondrial dysfunction …

Microglia shape the synaptic environment in health and disease, but synapses do not exist
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …

Persistent microglia-mediated neuroinflammation is a major pathophysiological contributor
to the progression of Parkinson's disease (PD), but the cell-signaling mechanisms governing …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …

Activation of innate immunity in the brain is a prominent feature of Alzheimer's disease (AD).
The present study investigated the regulation of innate immunity by wild-type serum injection …

Recognition of pathogen-or damage-associated molecular patterns (PAMPs, DAMPs) by
innate Toll-like receptors (TLRs) is central to the activation of microglia (brain macrophages) …

Neuroinflammation is a key pathological feature in neurological diseases, including
Alzheimer's disease (AD). The nucleotide-binding domain leucine-rich repeat-containing …

Neutrophil extracellular traps (NETs) exert a novel function of trapping pathogens. Released
NETs can accumulate in inflamed tissues, be recognized by other immune cells for …

Objectives Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious phenotype
of systemic lupus erythematosus (SLE). The disturbance of neuron–microglia crosstalk is …

The central nervous system manifestations of SLE (neuropsychiatric lupus, NPSLE) occur
frequently, though are often difficult to diagnose and treat. Symptoms of NPSLE can be quite …