Glucan unmasking identifies regulators of temperature-induced translatome reprogramming in C. neoformans
ALM Bloom, D Goich, CM Knowles, JC Panepinto - Msphere, 2021 - Am Soc Microbiol
The cell walls of fungi are critical for cellular structure and rigidity but also serve as a major
communicator to alert the cell to the changing environment. In response to stresses …
communicator to alert the cell to the changing environment. In response to stresses …
Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming
ALM Bloom, RM Jin, J Leipheimer, JE Bard… - Nature …, 2019 - nature.com
A common feature shared by systemic fungal pathogens of environmental origin, such as
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …
Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses
TR O'Meara, SM Holmer, K Selvig, F Dietrich… - MBio, 2013 - Am Soc Microbiol
Infectious microorganisms often play a role in modulating the immune responses of their
infected hosts. We demonstrate that Cryptococcus neoformans signals through the Rim101 …
infected hosts. We demonstrate that Cryptococcus neoformans signals through the Rim101 …
Unraveling capsule biosynthesis and signaling networks in Cryptococcus neoformans
EH Jang, JS Kim, SR Yu, YS Bahn - Microbiology spectrum, 2022 - Am Soc Microbiol
The polysaccharide capsule of Cryptococcus neoformans—an opportunistic basidiomycete
pathogen and the major etiological agent of fungal meningoencephalitis—is a key virulence …
pathogen and the major etiological agent of fungal meningoencephalitis—is a key virulence …
Cross-kingdom infection of macrophages reveals pathogen-and immune-specific global reprogramming and adaptation
The interactions between a host and microbe drive the health and disease status of the host.
Of importance is the cause of dysbiosis in the presence of a pathogen, and critically, the …
Of importance is the cause of dysbiosis in the presence of a pathogen, and critically, the …
Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction
CM Knowles, D Goich, ALM Bloom, MC Kalem… - Mbio, 2023 - Am Soc Microbiol
In response to the host environment, the human pathogen Cryptococcus neoformans must
rapidly reprogram its translatome from one which promotes growth to one which is …
rapidly reprogram its translatome from one which promotes growth to one which is …
Tools for Assessing Translation in Cryptococcus neoformans
CM Knowles, KM McIntyre, JC Panepinto - Journal of Fungi, 2021 - mdpi.com
Cryptococcus neoformans is a ubiquitous environmental fungus capable of establishing an
infection in a human host. Rapid changes in environments and exposure to the host immune …
infection in a human host. Rapid changes in environments and exposure to the host immune …
Lactate signalling regulates fungal β-glucan masking and immune evasion
As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of
the innate immune response, and yet the commensal fungus Candida albicans is able to …
the innate immune response, and yet the commensal fungus Candida albicans is able to …
Translational regulation promotes oxidative stress resistance in the human fungal pathogen Cryptococcus neoformans
J Leipheimer, ALM Bloom, CS Campomizzi, Y Salei… - MBio, 2019 - Am Soc Microbiol
Cryptococcus neoformans is one of the few environmental fungi that can survive within a
mammalian host and cause disease. Although many of the factors responsible for …
mammalian host and cause disease. Although many of the factors responsible for …
A unique cell wall synthetic response evoked by glucosamine determines pathogenicity-associated fungal cellular differentiation
P Hu, H Ding, L Shen, GJ He, H Liu, X Tian, C Tao… - PLoS …, 2021 - journals.plos.org
The yeast-to-hypha transition is tightly associated with pathogenicity in many human
pathogenic fungi, such as the model fungal pathogen Cryptococcus neoformans, which is …
pathogenic fungi, such as the model fungal pathogen Cryptococcus neoformans, which is …