Neural and physiological factors underlying individual differences in the vulnerability to drug
abuse are the major questions remained to be determined. The present study described …

Conditioned place preference and locomotor sensitization are rodent behavioral models
commonly used to investigate the actions of drugs of abuse. However, few studies have …

High locomotor response to novelty is associated with ease of drug self-administration but
does not predict greater place-conditioning effects of drugs. Yet, the latter reflects context …

It is thought that rewarding experiences with drugs create strong contextual associations and
encourage repeated intake. In turn, repeated exposures to drugs of abuse make lasting …

Outbred, male Sprague–Dawley rats can be classified as either low or high cocaine
responders (LCRs or HCRs, respectively) based on cocaine-induced locomotor activity in an …

It has been speculated that an individual's response to novelty is a reliable predictor of its
vulnerability to develop addiction. However, the relationships between response to novelty …

Novelty-seeking in rodents, defined as enhanced specific exploration of novel situations, is
considered to predict the response of animals to drugs of abuse and, thus, allow “drug …

Rationale In previous studies, we have demonstrated that mice of the inbred strain
C57BL/6J (C57) are more susceptible to amphetamine-induced conditioned place …

The development and maintenance of cocaine addiction depend heavily on learned reward-
environment associations that can induce drug-seeking behavior and relapse …

Cocaine is a potent stimulant drug, but its stimulant effects can be substantially modulated
by environmental novelty versus familiarity. In this report, we varied exposures to a novel …