We recently conducted a set of two experiments to investigate the possible co-operation
between genetics and exposure to novelty on the putative locomotor inhibiting effects of low …

Previous studies have demonstrated that rats showing a strong locomotor response to a
novel environment have a greater locomotor response to psychostimulant drugs and more …

Background: Substance use disorder emerges in a small proportion of drug users and has
the characteristics of a chronic relapsing pathology. Aims: Our study aimed to demonstrate …

Rationale Drug addiction is a multifactorial disorder resulting from an interaction between
genetic and environmental factors, and negative and positive environmental conditions may …

A main challenge in the therapy of drug dependent individuals is to help them reactivate
interest in non-drug-associated activities. We previously developed a rat experimental …

Food-deprivation increases the reinforcing efficacy of cocaine and other drugs within self-
administration experiments. In this study, the effects of food-deprivation on cocaine-induced …

Human and animal laboratory studies show that adolescents and adults respond differently
to drugs and that drug administration during adolescence leads to different behavioral …

A pervasive finding in animal models of substance abuse is that associations form quickly
between contexts and drugs of abuse, such as cocaine. Studies of conditioned place …

Alcohol has been reported to modulate the reinforcing and aversive properties of cocaine.
Given these effects, the present study examined whether this interaction could be extended …

Classical conditioning and behavioural sensitisation of motor activity induced with cocaine
(10 mg/kg, ip) were examined using an unbiased two-compartment conditioned place …