Microglia are the primary immune cell of the brain and function to protect the central nervous
system (CNS) from injury and invading pathogens. In the homeostatic brain, microglia serve …

Neuroinflammation is considered one of the cardinal features of Alzheimer's disease (AD).
Neuritic plaques composed of amyloid β and neurofibrillary tangle-laden neurons are …

Abstract The Alzheimer's Association's Research roundtable met in April 2015 to explore the
role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The …

Contrary to early views, we now know that systemic inflammatory/immune responses
transmit to the brain. The microglia, the resident “macrophages” of the brain's innate immune …

Alzheimer's disease (AD) is a neurodegenerative disease that is of high importance to the
neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is …

Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder
characterized by the progressive loss of neurons, which typically leads to severe …

Neuroinflammation is now regarded as both an early event and prime mover in the
pathobiology of Alzheimer disease (AD), a neurodegenerative disease that represents a …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting elderly
people worldwide, which is mainly characterized by cerebral amyloid-beta (Aβ) plaque …

Alzheimer's disease (AD) is characterized by three major histopathological hallmarks: β-
amyloid deposits, neurofibrillary tangles and gliosis. While neglected for decades, the …

Alzheimer's disease (AD) is typified by a robust microglial-mediated inflammatory response
within the brain. Indeed, microglial accumulation around plaques in AD is one of the …