[HTML][HTML] Targeting bile acids and lipotoxicity for NASH treatment

JYL Chiang - Hepatology communications, 2017 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, affecting
approximately 20%-30% of the population in Western countries. Nonalcoholic …

Update on pparγ and nonalcoholic Fatty liver disease

GP Ables - PPAR research, 2012 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is the most common initial presentation of obesity
and insulin resistance. Uninterrupted progression of hepatic lipid accumulation often leads …

Miniseries: Established pharmacological targets for NASHFXR agonists in NASH treatment

L Adorini, M Trauner - Journal of Hepatology, 2023 - Elsevier
The farnesoid X receptor (FXR), a bile acid (BA)-activated nuclear receptor highly expressed
in liver and intestine, regulates the expression of genes involved in cholesterol and bile acid …

[HTML][HTML] Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance

GA Preidis, KH Kim, DD Moore - The Journal of clinical …, 2017 - Am Soc Clin Investig
The nuclear receptors PPARα (encoded by NR1C1) and farnesoid X receptor (FXR,
encoded by NR1H4) are activated in the liver in the fasted and fed state, respectively …

[PDF][PDF] Hepatoprotective effects of the dual peroxisome proliferator‐activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease …

B Staels, A Rubenstrunk, B Noel, G Rigou… - …, 2013 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver damage ranging from
simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. To date, no …

The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice

M Pawlak, E Baugé, W Bourguet, K De Bosscher… - Hepatology, 2014 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and strongly associated
with central obesity, dyslipidemia, and insulin resistance. According to the multiple-hit model …

[HTML][HTML] Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis

Y Jiao, Y Lu, X Li - Acta Pharmacologica Sinica, 2015 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is characterized by the aberrant accumulation of
triglycerides in hepatocytes in the absence of significant alcohol consumption, viral infection …

[HTML][HTML] Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease

JY Xu, ZP Li, L Zhang, G Ji - World Journal of Gastroenterology …, 2014 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome and is one of the most prevalent liver disorders worldwide. NAFLD can gradually …

FXR agonists as therapeutic agents for non-alcoholic fatty liver disease

RM Carr, AE Reid - Current atherosclerosis reports, 2015 - Springer
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic
syndrome and a risk factor for both cardiovascular and hepatic related morbidity and …

[HTML][HTML] Current role of fenofibrate in the prevention and management of non-alcoholic fatty liver disease

MS Kostapanos, A Kei, MS Elisaf - World journal of hepatology, 2013 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is a common health problem with a high mortality
burden due to its liver-and vascular-specific complications. It is associated with obesity, high …