[HTML][HTML] Targeting bile acids and lipotoxicity for NASH treatment
JYL Chiang - Hepatology communications, 2017 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, affecting
approximately 20%-30% of the population in Western countries. Nonalcoholic …
approximately 20%-30% of the population in Western countries. Nonalcoholic …
Update on pparγ and nonalcoholic Fatty liver disease
GP Ables - PPAR research, 2012 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is the most common initial presentation of obesity
and insulin resistance. Uninterrupted progression of hepatic lipid accumulation often leads …
and insulin resistance. Uninterrupted progression of hepatic lipid accumulation often leads …
Miniseries: Established pharmacological targets for NASHFXR agonists in NASH treatment
L Adorini, M Trauner - Journal of Hepatology, 2023 - Elsevier
The farnesoid X receptor (FXR), a bile acid (BA)-activated nuclear receptor highly expressed
in liver and intestine, regulates the expression of genes involved in cholesterol and bile acid …
in liver and intestine, regulates the expression of genes involved in cholesterol and bile acid …
[HTML][HTML] Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance
The nuclear receptors PPARα (encoded by NR1C1) and farnesoid X receptor (FXR,
encoded by NR1H4) are activated in the liver in the fasted and fed state, respectively …
encoded by NR1H4) are activated in the liver in the fasted and fed state, respectively …
[PDF][PDF] Hepatoprotective effects of the dual peroxisome proliferator‐activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease …
Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver damage ranging from
simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. To date, no …
simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. To date, no …
The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and strongly associated
with central obesity, dyslipidemia, and insulin resistance. According to the multiple-hit model …
with central obesity, dyslipidemia, and insulin resistance. According to the multiple-hit model …
[HTML][HTML] Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis
Y Jiao, Y Lu, X Li - Acta Pharmacologica Sinica, 2015 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is characterized by the aberrant accumulation of
triglycerides in hepatocytes in the absence of significant alcohol consumption, viral infection …
triglycerides in hepatocytes in the absence of significant alcohol consumption, viral infection …
[HTML][HTML] Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease
JY Xu, ZP Li, L Zhang, G Ji - World Journal of Gastroenterology …, 2014 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome and is one of the most prevalent liver disorders worldwide. NAFLD can gradually …
syndrome and is one of the most prevalent liver disorders worldwide. NAFLD can gradually …
FXR agonists as therapeutic agents for non-alcoholic fatty liver disease
RM Carr, AE Reid - Current atherosclerosis reports, 2015 - Springer
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic
syndrome and a risk factor for both cardiovascular and hepatic related morbidity and …
syndrome and a risk factor for both cardiovascular and hepatic related morbidity and …
[HTML][HTML] Current role of fenofibrate in the prevention and management of non-alcoholic fatty liver disease
MS Kostapanos, A Kei, MS Elisaf - World journal of hepatology, 2013 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is a common health problem with a high mortality
burden due to its liver-and vascular-specific complications. It is associated with obesity, high …
burden due to its liver-and vascular-specific complications. It is associated with obesity, high …