Saroglitazar, a PPAR‐α/γ agonist, for treatment of NAFLD: a randomized controlled double‐blind phase 2 trial

S Gawrieh, M Noureddin, N Loo, R Mohseni… - …, 2021 - Wiley Online Library
Background and Aims NAFLD is characterized by insulin resistance and dysregulated lipid
and glucose metabolism. Saroglitazar, a dual peroxisome proliferator activated receptor‐α/γ …

[PDF][PDF] Bile acids and nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

JP Arab, SJ Karpen, PA Dawson, M Arrese… - …, 2017 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an
important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing …

Role of FXR in bile acid and metabolic homeostasis in NASH: pathogenetic concepts and therapeutic opportunities

R Radun, M Trauner - Seminars in Liver Disease, 2021 - thieme-connect.com
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent cause of liver
disease, increasingly contributing to the burden of liver transplantation. In search for …

[PDF][PDF] The nuclear receptor FXR, but not LXR, up-regulates bile acid transporter expression in non-alcoholic fatty liver disease

NE Aguilar-Olivos, D Carrillo-Córdova… - Annals of …, 2015 - medigraphic.com
Background. Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic
liver disease. Patients with non-alcoholic steatohepatitis (NASH) have increased plasmatic …

Liver protective effect of fenofibrate in NASH/NAFLD animal models

A Mahmoudi, SA Moallem, TP Johnston… - PPAR …, 2022 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is initiated by excessive fat buildup in the liver,
affecting around 35% of the world population. Various circumstances contribute to the …

Current pharmacological treatment of nonalcoholic fatty liver

P Portincasa, I Grattagliano, VO Palmieri… - Current medicinal …, 2006 - ingentaconnect.com
Nonalcoholic fatty liver disease (NAFLD) is a frequent and potentially progressive chronic
liver disease that occurs in subjects who do not abuse alcohol. NAFLD is often associated …

[PDF][PDF] Fibrates and cholestasis

NS Ghonem, DN Assis, JL Boyer - Hepatology, 2015 - Wiley Online Library
Cholestasis, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis
(PSC), results from an impairment or disruption of bile production and causes intracellular …

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

A Montagner, A Polizzi, E Fouché, S Ducheix, Y Lippi… - Gut, 2016 - gut.bmj.com
Objective Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor
expressed in tissues with high oxidative activity that plays a central role in metabolism. In …

FXR and NASH: an avenue for tissue-specific regulation

Z Henry, V Meadows, GL Guo - Hepatology communications, 2023 - journals.lww.com
NASH is within the spectrum of NAFLD, a liver condition encompassing liver steatosis,
inflammation, hepatocyte injury, and fibrosis. The prevalence of NASH-induced cirrhosis is …

Treatments for NAFLD: state of art

A Mantovani, A Dalbeni - International journal of molecular sciences, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is to date the most common chronic liver disease
in clinical practice and, consequently, a major health problem worldwide. It affects …