Hepatocytes are the major cell-type in the liver responsible for the coordination of
metabolism in response to multiple signaling inputs. Coordination occurs primarily at the …

Oxidative stress is a key driver in the development and progression of several diseases,
including metabolic associated fatty liver disease (MAFLD). This condition includes a wide …

Nonalcoholic steatohepatitis (NASH) comprises dysregulation of lipid metabolism and
inflammation. Identification of the various genetic and environmental susceptibility factors for …

Nonalcoholic fatty liver disease (NAFLD) has an estimated prevalence of 25% in the general
population, and cirrhosis secondary to nonalcoholic steatohepatitis (NASH) is predicted to …

The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that is
mainly expressed in liver, intestine, kidney and adipose tissue. On activation by bile acids …

Nonalcoholic fatty liver disease (NAFLD) is recognized as the most common cause of
chronic liver disease worldwide. NAFLD is a clinicopathologic syndrome ranging from …

Non-alcoholic fatty liver disease (NAFLD) is an emerging global disease with increasing
prevalence. However, the mechanism of NAFLD development is not fully understood. To …

The metabolic syndrome encompasses metabolic and cardiovascular risk factors which
predict diabetes and cardiovascular disease (CVD) better than any of its individual …

Nonalcoholic fatty liver disease (NAFLD), a series of liver metabolic disorders manifested by
lipid accumulation within hepatocytes, has become the primary cause of chronic liver …

Introduction: Novel peroxisome proliferator-activated receptor (PPAR) modulators (selective
PPAR modulators [SPPARMs]) and dual PPAR agonists may have an important role in the …