Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder and is
strongly associated with obesity and type 2 diabetes. Currently, there is no approved …

Objective The aim of this study was to explore the role of farnesoid X receptor (FXR) in liver
lipid metabolism of non-alcoholic fatty liver disease (NAFLD) patients. Methods In this study …

Reactive oxygen species, when released under controlled conditions and limited amounts,
contribute to cellular proliferation, senescence, and survival by acting as signaling …

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …

Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic
syndrome, is a complex multifactorial disease characterized by metabolic deregulations that …

Non-alcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in
Western countries, ranging from simple steatosis to steatohepatitis, cirrhosis, and …

NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Epidermal growth factor receptor (EGFR) is a critical regulator of hepatocyte proliferation
and liver regeneration. Our recent work indicated that EGFR can also regulate lipid …

Introduction: Triglyceride accumulation in the liver is an early feature in the development of
nonalcoholic fatty liver disease (NAFLD) associated with human obesity, which is a …

Background Recent studies have shown that dysregulation of autophagy is involved in the
development of nonalcoholic fatty liver disease (NAFLD). Transcription factors E3 (TFE3) …