Study Objective: To determine whether wheezing on maximal forced exhalation is a
predictor of asthma in persons with normal or nearly normal baseline spirometry. Design …

Background: In diagnosing cough due to asthma, methacholine chloride inhalation
challenge (MIC) interpreted in a traditional fashion has been shown to have positive …

To determine the predictive value of wheeze compared to methacholine inhalation
challenge (MIC) in diagnosing asthma, we prospectively evaluated 34 patients considered …

Asthma is characterized by airway inflammation, airway hyper-responsiveness (AHR) and
variable air flow obstruction. The diagnosis of asthma, however, is often based upon …

Wheezing is a nonspecific manifestation of airway obstruction. Even though bronchial
asthma is the most common cause of wheezing, a variety of pulmonary and nonpulmonary …

The frequency with which disagreement occurs between the clinician's diagnosis of asthma
and the objective measurement of methacholine airway responsiveness is not known. We …

Methacholine inhalation tests are used to help in the diagnosis of asthma when spirometry is
normal. However, the significance of increased methacholine responsiveness in patients …

• Methacholine challenge has been proposed as a diagnostic test in situations where clinical
asthma is suspected but reversible airway obstruction cannot be demonstrated …

The appearance of wheezes and changes in inspiratory breath (vesicular) sound intensity
(BSI) were monitored in patients undergoing routine methacholine challenge test (MCT) …

If the diagnosis of asthma is in question, eg, if the patient has symptoms that suggest asthma
(either typical symptoms such as coughing, wheezing, and dyspnea or atypical symptoms) …