Endoderm development is dependent on inductive signals from different structures in close
vicinity, including the notochord, lateral plate mesoderm and endothelial cells. Recently, we …

Vascular endothelial growth factor (VEGF) is an angiogenic factor and a potent stimulator of
microvascular permeability. It is a mitogen specific for endothelial cells. The expression of …

Type 2 diabetes mellitus (T2DM) affects millions of people and is linked with obesity and
lipid accumulation in peripheral tissues. Increased lipid handling and lipotoxicity in insulin …

Angiopoietin-1 (Ang-1) and its receptor Tie-2, a trans-membrane tyrosine kinase uniquely
expressed by endothelial cells, are shown by null mutation studies to be essential to …

Organogenesis requires tightly coordinated and patterned growth of numerous cell types to
form a fully mature and vascularized organ. Endothelial cells (ECs) that line blood vessels …

Type 1 and type 2 diabetes result from an absolute or relative reduction in functional β-cell
mass. One approach to replacing lost β-cell mass is transplantation of cadaveric islets; …

Angiogenesis is a complex multistep process by which new blood vessels are formed from
the preexisting vasculature. 1, 2 Angiogenesis is a crucial event in normal embryonic …

Background. Delayed angiogenesis remains a significant challenge to the survival of
transplanted islets. In this study, using a murine model of subcutaneous islet transplantation …

Angiopoietins 1 and 2, ligands for the receptor kinase Tie-2, have been proposed to play
critical but opposing roles in vascular development. Since signaling by Tie-2 is likely …

Angiogenesis, the formation of new networks of blood vessels, has essential roles in
embryonic development, organ homeostasis and disease progression. Several signalling …