The vascular wall is mainly composed of endothelial cells (ECs) and smooth muscle cells
(SMCs). The crosstalking between these two cell types is critical in the vascular maturation …

Vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGFβ) are
potent regulators of angiogenesis. How VEGF and TGFβ signaling pathways crosstalk is not …

V asculogenesis and angiogenesis are the funda-mental processes by which new blood
vessels are formed (Carmeliet, 2000; Risau, 1997; Risau and Flamme, 1995) …

Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate
a role for blood vessels as a source of developmental signals during pancreatic …

Integrin α3β1 is a major receptor for laminin. The expression levels of laminins-8 and− 10 in
the basement membrane surrounding blood vessels are known to change during tumor …

Blood vessels form a highly branched, interconnected, and largely stereotyped network of
tubes that sustains every organ and tissue in vertebrates. How vessels come to take on their …

Endothelial insulin receptors (Insr) promote sprouting angiogenesis, although the
underpinning cellular and molecular mechanisms are unknown. Comparing mice with whole …

Recent studies, particularly of genetically altered mice, have greatly improved our
understanding of the molecular basis underlying the development of the vascular system …

Angiogenesis, the growth of new vessels from pre-existing blood vessels, requires complex
signaling pathways and a high degree of spatial and temporal coordination among various …

Background Vascular endothelial growth factor (VEGF) is a highly conserved, master
regulatory molecule required for endothelial cell proliferation, organization, migration and …