The cationic porphyrin TMPyP4 is a well-established DNA G-quadruplex (G4) binding ligand
that can stabilize different topologies via multiple binding modes. However, TMPyP4 can …

The ability to control the folding topology of DNA G‐quadruplexes allows for rational design
of quadruplex‐based scaffolds for potential use in various therapeutic and technological …

The inclination of guanosine monophosphate (GMP) or guanine-rich poly-and
oligonucleotides to self-assemble has been recognized for several decades. 1–4 G …

G-Quadruplexes are noncanonical nucleic acid secondary structures based on guanine
association that are readily adopted by G-rich RNA and DNA sequences. Naturally occurring …

A class of DNA folds/structures known collectively as G-quadruplexes (G4) commonly forms
in guanine-rich areas of genomes. G4-DNA is thought to have a functional role in the …

We present the direct and single‐molecule visualization of the in‐pathway intermediates of
the G‐quadruplex folding that have been inaccessible by any experimental method …

Thermodynamic studies of G-quadruplex stability are an essential complement to structures
obtained by NMR or X-ray crystallography. An understanding of the energetics of …

Current state-of-the art explicit-solvent atomistic molecular dynamics (MD) simulations are
reviewed. We describe the basic principles and limitations of MD methodology. We also …

G-quadruplexes (Gqs) are guanine-rich DNA structures formed by single-stranded DNA.
They are of paramount significance to gene expression regulation, but also drug targets for …

DNA G-quadruplexes are non-canonical DNA structures, which have been proved to play an
important role in key biological processes, such as gene expression, replication, regulation …