It is now known that variations in extracellular calcium concentration exert diverse
physiologic effects in a variety of tissues that are mediated by a calcium-sensing receptor …

The calcium-sensing receptor (CaSR) is a homodimeric G-protein-coupled receptor that
signals via intracellular calcium (Ca2+ i) mobilisation and phosphorylation of extracellular …

The CaSR is a class CG protein-coupled receptor (GPCR) that acts as a multimodal
chemosensor to maintain diverse homeostatic functions. The CaSR is a clinical therapeutic …

Calcium-sensing receptors (CaSRs) are class CG protein-coupled receptors that respond to
physiological activators, including extracellular Ca2+ (Cao2+) and l-amino acids as well as …

Activating mutations of calcium‐sensing receptor (CaSR) cause autosomal dominant
hypocalcemia (ADH). ADH patients develop hypocalcemia, hyperphosphatemia, and …

Autosomal dominant hypocalcemia can be caused by activating mutations of the calcium-
sensing receptor (CaSR) gene. We experienced two patients (proband and her daughter) …

Context: Persistent hypercalciuria, with the attendant risk of nephrocalcinosis and eventual
renal failure, is common in hypoparathyroid patients, especially those with activating …

Calcium sensing receptor (CaSR) mutations or altered expression cause disorders of
calcium handling. Recent studies suggest that reduced targeting to the plasma membrane is …

In addition to its prominent role in the parathyroid gland, the calcium-sensing receptor
(CaSR) is expressed in various tissues, including the kidney. This article reviews current …

Objective: Autosomal dominant hypocalcemia (ADH) is a congenital isolated
hypoparathyroidism caused by activating mutations in the calcium-sensing receptor (CASR) …