A neonate affected by a novel inactivating mutation in the calcium-sensing receptor (CASR)
gene is presented. This mutation is homozygously inherited and has not been previously …

Calcium‐sensing receptors (CaSR) are integral to regulation of systemic Ca2+ homeostasis.
Altered expression levels or mutations in CaSR cause Ca2+ handling diseases. CaSR is …

The calcium sensing receptor (CaSR) is a class C G-protein-coupled receptor that is crucial
for the feedback regulation of extracellular free ionised calcium homeostasis. While …

The calcium-sensing receptor is a G protein-coupled receptor that has a key role in
extracellular calcium homeostasis, regulating the secretion of parathyroid hormone and the …

The discovery of a G protein–coupled, calcium-sensing receptor (CaR) a decade ago and of
diseases caused by CaR mutations provided unquestionable evidence of the CaR's critical …

The calcium-sensing receptor (CaSR), a cell-surface sensor for Ca2+, is the master
regulator of calcium homeostasis in humans and is the target of calcimimetic drugs for the …

OBJECTIVES:: The calcium-sensing receptor (CASR) is critical for maintenance of blood
calcium in a narrow physiologic range. Naturally occurring mutations in the calcium-sensing …

The calcium-sensing receptor (CaSR) regulates organismal Ca2+ homeostasis.
Dysregulation of CaSR expression or mutations in the CASR gene cause disorders of Ca2+ …

Parathyroid hormone (PTH) secreted from parathyroid cells is a key regulator of circulating
levels of calcium ion, which is maintained within a narrow physiological range mainly by the …

The calcium-sensing receptor (CASR), a member of the G-protein coupled receptor family, is
expressed in both parathyroid and kidney, and aids these organs in sensing extracellular …