Integrative approaches generate insights into the architecture of non-syndromic cleft lip with or without cleft palate
J Welzenbach, NL Hammond, M Nikolić… - Human Genetics and …, 2021 - cell.com
Non-syndromic cleft lip with or without cleft palate (nsCL/P) is a common congenital facial
malformation with a multifactorial etiology. Genome-wide association studies (GWASs) have …
malformation with a multifactorial etiology. Genome-wide association studies (GWASs) have …
Prioritization of non-coding elements involved in non-syndromic cleft lip with/without cleft palate through genome-wide analysis of de novo mutations
HK Zieger, L Weinhold, A Schmidt, M Holtgrewe… - Human Genetics and …, 2023 - cell.com
Non-syndromic cleft lip with/without cleft palate (nsCL/P) is a highly heritable facial disorder.
To date, systematic investigations of the contribution of rare variants in non-coding regions …
To date, systematic investigations of the contribution of rare variants in non-coding regions …
Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology
LJ Howe, MK Lee, GC Sharp, G Davey Smith… - PLoS …, 2018 - journals.plos.org
There is increasing evidence that genetic risk variants for non-syndromic cleft lip/palate
(nsCL/P) are also associated with normal-range variation in facial morphology. However …
(nsCL/P) are also associated with normal-range variation in facial morphology. However …
Genome-wide association study identifies a new susceptibility locus for cleft lip with or without a cleft palate
Y Sun, Y Huang, A Yin, Y Pan, Y Wang, C Wang… - Nature …, 2015 - nature.com
Nonsyndromic cleft lip with or without a cleft palate (NSCL/P) is among the most common
human congenital birth defects and imposes a substantial physical and financial burden on …
human congenital birth defects and imposes a substantial physical and financial burden on …
Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity
Y Yu, X Zuo, M He, J Gao, Y Fu, C Qin, L Meng… - Nature …, 2017 - nature.com
Non-syndromic cleft lip with palate (NSCLP) is the most serious sub-phenotype of non-
syndromic orofacial clefts (NSOFC), which are the most common craniofacial birth defects in …
syndromic orofacial clefts (NSOFC), which are the most common craniofacial birth defects in …
A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24. 2, 17q23 and 19q13
Orofacial clefts (OFCs), which include non-syndromic cleft lip with or without cleft palate
(CL/P), are among the most common birth defects in humans, affecting approximately 1 in …
(CL/P), are among the most common birth defects in humans, affecting approximately 1 in …
Whole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip/palate
W Awotoye, PA Mossey, JB Hetmanski, LJJ Gowans… - Scientific reports, 2022 - nature.com
Abstract The majority (85%) of nonsyndromic cleft lip with or without cleft palate (nsCL/P)
cases occur sporadically, suggesting a role for de novo mutations (DNMs) in the etiology of …
cases occur sporadically, suggesting a role for de novo mutations (DNMs) in the etiology of …
DeepFace: Deep learning-based framework to contextualize orofacial cleft-related variants during human embryonic craniofacial development
Orofacial clefts (OFC) are among the most common human congenital birth defects.
Previous multiethnic studies have identified dozens of associated loci for both cleft lip with or …
Previous multiethnic studies have identified dozens of associated loci for both cleft lip with or …
Genetic inheritance models of non-syndromic cleft lip with or without palate: from monogenic to polygenic
X Cheng, F Du, X Long, J Huang - Genes, 2023 - mdpi.com
Non-syndromic cleft lip with or without palate (NSCL/P) is a prevalent birth defect that affects
1/500–1/1400 live births globally. The genetic basis of NSCL/P is intricate and involves both …
1/500–1/1400 live births globally. The genetic basis of NSCL/P is intricate and involves both …
CleftGeneDB: a resource for annotating genes associated with cleft lip and cleft palate
Cleft lip with/without cleft palate (CL/P) is one of the most common congenital human birth
defects with a prevalence estimated at approximately 1/700 live births worldwide, varying …
defects with a prevalence estimated at approximately 1/700 live births worldwide, varying …