Background The expanding set of genomics tools available for inbred mouse strains has
renewed interest in phenotyping larger sets of strains. The present study aims to explore …

Large individual differences exist among mice in their behavioral responses to drugs of
abuse, and many of these differences have a substantial genetic basis. The creation of new …

Rationale Age of initial exposure to addictive substances is inversely proportional to risk of
developing drug dependence. There is debate, however, as to whether intake at a young …

Rationale In previous studies, we have demonstrated that mice of the inbred strain
C57BL/6J (C57) are more susceptible to amphetamine-induced conditioned place …

Conditioned place preference and locomotor sensitization are rodent behavioral models
commonly used to investigate the actions of drugs of abuse. However, few studies have …

Outbred, male Sprague–Dawley rats can be classified as either low or high cocaine
responders (LCRs or HCRs, respectively) based on cocaine-induced locomotor activity in an …

Initial sensitivity to psychostimulants can predict subsequent use and abuse in humans.
Acute locomotor activation in response to psychostimulants is commonly used as an animal …

Cocaine use disorders (CUD) are devastating for affected individuals and impose a
significant societal burden, but there are currently no FDA-approved therapies. The …

The rewarding effect of cocaine as reflected by the development of conditioned place
preference was examined in C57BL/6J and 129/J mice. Cocaine was administered in a …

It has been speculated that an individual's response to novelty is a reliable predictor of its
vulnerability to develop addiction. However, the relationships between response to novelty …