Mechanisms of neutrophil‐induced parenchymal cell injury

H Jaeschke, CW Smith - Journal of leukocyte biology, 1997 - Wiley Online Library
Neutrophils are involved in organ damage induced by an excessive acute inflammatory
response after ischemia‐reperfusion, trauma, and sepsis. In addition to causing vascular …

Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils

H Jaeschke, CW Smith, MG Clemens, PE Ganey… - Toxicology and applied …, 1996 - Elsevier
During recent years, increasing experimental evidence has suggested that hepatic
nonparenchymal cells, in particular Kupffer cells and neutrophils, can contribute significantly …

Role of neutrophils in the pathogenesis of acute inflammatory liver injury

SK Ramaiah, H Jaeschke - Toxicologic pathology, 2007 - journals.sagepub.com
Polymorphonuclear leukocytes (neutrophils) are essential in the defense against invading
microorganisms, tissue trauma or any inciting inflammatory signals. Hepatic infiltration of …

Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions

H Jaeschke - American Journal of Physiology …, 2006 - journals.physiology.org
Polymorphonuclear leukocytes (neutrophils) are a vital part of the innate immune response
to microbial infections and tissue trauma, eg, ischemia-reperfusion injury, in many organs …

Role of neutrophils in acute inflammatory liver injury

H Jaeschke, T Hasegawa - Liver International, 2006 - Wiley Online Library
Hepatic infiltration of polymorphonuclear leukocytes (neutrophils) is an early response to
tissue injury, cellular stress or systemic inflammation. Neutrophil activation is vital for host …

[HTML][HTML] Neutrophils: a cornerstone of liver ischemia and reperfusion injury

THC de Oliveira, PE Marques, P Proost… - Laboratory …, 2018 - Elsevier
Ischemia-reperfusion injury (IRI) is the main cause of morbidity and mortality due to graft
rejection after liver transplantation. During IRI, an intense inflammatory process occurs in the …

Neutrophil margination and extravasation in sinusoids and venules of liver during endotoxin-induced injury

JG Chosay, NA Essani, CJ Dunn… - American Journal of …, 1997 - journals.physiology.org
Neutrophils contribute to liver damage during endotoxin shock. The objective of this
investigation was to document where neutrophils localize in the hepatic vasculature and …

Neutrophils and intravascular immunity in the liver during infection and sterile inflammation

B McDonald, P Kubes - Toxicologic pathology, 2012 - journals.sagepub.com
The liver is a target of many inflammatory pathologies of both infectious and noninfectious
etiology. As key effectors of the innate immune system, neutrophils are critical for defense …

Cytokine cascades and the hepatic inflammatory response to ischemia and reperfusion

T Okaya, AB Lentsch - Journal of Investigative Surgery, 2003 - Taylor & Francis
Ischemia/reperfusion injury of the liver has two distinct phases that contribute to hepatocyte
damage. The acute phase is characterized by Kupffer cell production of reactive oxygen …

The role of neutrophils in the development of liver diseases

R Xu, H Huang, Z Zhang, FS Wang - Cellular & molecular immunology, 2014 - nature.com
Liver disease encompasses a wide variety of liver conditions, including liver failure, liver
cirrhosis and a spectrum of acute and chronic hepatitis, such as alcoholic, fatty, drug, viral …