[HTML][HTML] TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways
SB Haudek, GE Taffet, MD Schneider… - The Journal of clinical …, 2007 - Am Soc Clin Investig
Transgenic mice with cardiac-restricted overexpression of secretable TNF (MHCsTNF)
develop progressive LV wall thinning and dilation accompanied by an increase in …
develop progressive LV wall thinning and dilation accompanied by an increase in …
Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression
D Engel, R Peshock, RC Armstong… - American Journal …, 2004 - journals.physiology.org
Although cardiac myocyte apoptosis has been detected in explanted hearts from patients
with end-stage dilated and ischemic cardiomyopathy, the relative contribution of apoptotic …
with end-stage dilated and ischemic cardiomyopathy, the relative contribution of apoptotic …
Overexpression of tumor necrosis factor-α activates both anti-and pro-apoptotic pathways in the myocardium
T Kubota, M Miyagishima, CS Frye, SM Alber… - Journal of Molecular and …, 2001 - Elsevier
We have previously reported that mice with cardiac-specific overexpression of tumor
necrosis factor (TNF)-α develop myocardial inflammation, cardiac hypertrophy, and dilated …
necrosis factor (TNF)-α develop myocardial inflammation, cardiac hypertrophy, and dilated …
Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-α
T Kubota, CF McTiernan, CS Frye, SE Slawson… - Circulation …, 1997 - Am Heart Assoc
The failing human heart expresses tumor necrosis factor-α (TNF-α). However, its
pathophysiological significance is not clear. We previously reported that robust …
pathophysiological significance is not clear. We previously reported that robust …
Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-α
D Bryant, L Becker, J Richardson, J Shelton, F Franco… - Circulation, 1998 - Am Heart Assoc
Background—Tumor necrosis factor-α (TNF-α) is a multifunctional cytokine that has been
detected in several human cardiac-related conditions, including congestive heart failure and …
detected in several human cardiac-related conditions, including congestive heart failure and …
Gene expression profiling during the transition to failure in TNF-α over-expressing mice demonstrates the development of autoimmune myocarditis
Z Tang, BS McGowan, SA Huber, CF McTiernan… - Journal of molecular and …, 2004 - Elsevier
Transgenic mice with cardiac-specific over-expression of tumor necrosis factor-α (TNF1. 6)
progress to dilated heart failure. A significant inflammatory response precedes functional …
progress to dilated heart failure. A significant inflammatory response precedes functional …
Bidirectional regulation of nuclear factor-κB and mammalian target of rapamycin signaling functionally links Bnip3 gene repression and cell survival of ventricular …
Background—Tumor necrosis factor-α and other proinflammatory cytokines activate the
canonical Nuclear Factor (NF)-κB pathway through the kinase IKKβ. Previously, we …
canonical Nuclear Factor (NF)-κB pathway through the kinase IKKβ. Previously, we …
Cardiomyocyte NF-κB p65 promotes adverse remodelling, apoptosis, and endoplasmic reticulum stress in heart failure
T Hamid, SZ Guo, JR Kingery, X Xiang… - Cardiovascular …, 2011 - academic.oup.com
Aims The role of nuclear factor (NF)-κB in heart failure (HF) is not well defined. We sought to
determine whether myocyte-localized NF-κB p65 activation in HF exacerbates post …
determine whether myocyte-localized NF-κB p65 activation in HF exacerbates post …
Morphological and functional changes in cardiac myocytes isolated from mice overexpressing TNF-α
AM Janczewski, T Kadokami… - American Journal …, 2003 - journals.physiology.org
Transgenic (TG) TNF1. 6 mice, which cardiac specifically overexpress tumor necrosis factor-
α (TNF-α), exhibit heart failure (HF) and increased mortality, which is markedly higher in …
α (TNF-α), exhibit heart failure (HF) and increased mortality, which is markedly higher in …
Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor
N Sivasubramanian, ML Coker, KM Kurrelmeyer… - Circulation, 2001 - Am Heart Assoc
Background The mechanisms responsible for tumor necrosis factor (TNF)–induced LV
structural remodeling in the adult heart are not known. Methods and Results We generated a …
structural remodeling in the adult heart are not known. Methods and Results We generated a …
相关搜索
- cardiomyocyte apoptosis cardiac remodeling
- transgenic mice cardiac failure
- transgenic mice tumor necrosis
- transgenic mice myocyte apoptosis
- transgenic mice tnf overexpression
- transgenic mice ventricular remodeling
- transgenic mice dilated cardiomyopathy
- ventricular myocytes cell survival
- transgenic mice myocardial expression
- tnf overexpression myocyte apoptosis
- cardiac myocytes tnf α
- bidirectional regulation cell survival
- gene repression cell survival
- mammalian target cell survival
- nuclear factor cell survival