Transgenic mice with cardiac-restricted overexpression of secretable TNF (MHCsTNF)
develop progressive LV wall thinning and dilation accompanied by an increase in …

Although cardiac myocyte apoptosis has been detected in explanted hearts from patients
with end-stage dilated and ischemic cardiomyopathy, the relative contribution of apoptotic …

We have previously reported that mice with cardiac-specific overexpression of tumor
necrosis factor (TNF)-α develop myocardial inflammation, cardiac hypertrophy, and dilated …

The failing human heart expresses tumor necrosis factor-α (TNF-α). However, its
pathophysiological significance is not clear. We previously reported that robust …

Background—Tumor necrosis factor-α (TNF-α) is a multifunctional cytokine that has been
detected in several human cardiac-related conditions, including congestive heart failure and …

Transgenic mice with cardiac-specific over-expression of tumor necrosis factor-α (TNF1. 6)
progress to dilated heart failure. A significant inflammatory response precedes functional …

Background—Tumor necrosis factor-α and other proinflammatory cytokines activate the
canonical Nuclear Factor (NF)-κB pathway through the kinase IKKβ. Previously, we …

Aims The role of nuclear factor (NF)-κB in heart failure (HF) is not well defined. We sought to
determine whether myocyte-localized NF-κB p65 activation in HF exacerbates post …

Transgenic (TG) TNF1. 6 mice, which cardiac specifically overexpress tumor necrosis factor-
α (TNF-α), exhibit heart failure (HF) and increased mortality, which is markedly higher in …

Background The mechanisms responsible for tumor necrosis factor (TNF)–induced LV
structural remodeling in the adult heart are not known. Methods and Results We generated a …