The third complement component (C3) is a multifunctional glycoprotein that interacts with
numerous serum proteins, cell surface receptors, and membrane-associated regulatory …

The third component of complement is central to both pathways of the complement cascade
and in mediating or initiating the bulk of physiological and often pathological effects of this …

Complement component C6 is a part of the lytic membrane attack complex formed during
complement activation. Animal modeling to define the role of C5a vs. C5b-9 in human …

Hereditary deficiency of the third component of complement, C3, is found very seldom in the
human. C3 deficiency is associated with severe bacterial infections revealing the central role …

Genetic deficiencies of the complement protein C3 occur naturally in humans and animal
models and have been induced in mice by targeted deletion of the C3 gene. The study of …

Genetic deficiency of the second component of complement (C2) is the most common
complement-deficiency state among Western Europeans and is frequently associated with …

We recently described a case of hereditary complement C3 deficiency (C3D) in a New
Zealand male who has a small amount of serum C3 (7 micrograms/ml), a normal size 5.2 …

We report studies of complement-mediated functions in the third family with C5 deficiency.
Four siblings in this black family were found to be C5 deficient (C5-D). All deficient members …

Genetically determined deficiency of the third component of complement (C3) in the dog is
characterized by a predisposition to recurrent bacterial infections and to type 1 …

To ascertain the molecular mechanism that causes murine C5 deficiency, genomic and
cDNA libraries were constructed from mouse liver DNA and mRNA employing the congenic …