Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington's disease via suppressing MAPKs and NF-κB pathways …

X Yang, S Chu, Z Wang, F Li, Y Yuan… - Acta Pharmacologica …, 2021 - nature.com
Huntington's disease (HD) is one of main neurodegenerative diseases, characterized by
striatal atrophy, involuntary movements, and motor incoordination. Ginsenoside Rg1 (Rg1) …

Rg1 improves LPS-induced Parkinsonian symptoms in mice via inhibition of NF-κB signaling and modulation of M1/M2 polarization

J Liu, M Zhao, Z Zhang, L Cui, X Zhou… - Acta Pharmacologica …, 2020 - nature.com
Ginsenoside Rg1 is one of the most active ingredients in ginseng, which has been reported
to protect dopaminergic neurons and improve behavioral defects in MPTP model, 6-OHDA …

[HTML][HTML] Ginsenoside compound K reduces the progression of Huntington's disease via the inhibition of oxidative stress and overactivation of the ATM/AMPK pathway

KF Hua, AC Chao, TY Lin, WT Chen, YC Lee… - Journal of Ginseng …, 2022 - Elsevier
Background Huntington's disease (HD) is a neurodegenerative disorder caused by the
expansion of trinucleotide CAG repeat in the Huntingtin (Htt) gene. The major pathogenic …

Ginsenoside Rg1 reduces MPTP‐induced substantia nigra neuron loss by suppressing oxidative stress1

X CHEN, Y ZHOU, Y Chen, Y ZHU… - Acta Pharmacologica …, 2005 - Wiley Online Library
Aim: To investigate the effect of ginsenoside Rg1, an effective ingredient from ginsenoside,
on 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP)‐induced substantia nigra …

Ginsenoside Rg1 ameliorates motor function in an animal model of Parkinson's disease

W Jiang, Z Wang, Y Jiang, M Lu, X Li - Pharmacology, 2015 - karger.com
Aims: Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of
dopaminergic neurons in the substantia nigra (SN) and diminished dopamine levels in the …

Ginsenoside Re exhibits neuroprotective effects by inhibiting neuroinflammation via CAMK/MAPK/NF‑κB signaling in microglia

I Madhi, JH Kim, JE Shin, Y Kim - Molecular Medicine …, 2021 - spandidos-publications.com
Abstract Ginsenoside Re (G‑Re) is a panaxatriol saponin and one of the pharmacologically
active natural constituents of ginseng (Panax ginseng CA Meyer). G‑Re has antioxidant, anti …

Glycyrrhizin prevents 3-nitropropionic acid-induced neurotoxicity by downregulating HMGB1/TLR4/NF-κB p65 signaling, and attenuating oxidative stress, inflammation …

AM Gendy, HM El-Sadek, MM Amin, KA Ahmed… - Life Sciences, 2023 - Elsevier
Abstract Aims Glycyrrhizin (Glyc) is a saponin triterpenoid that has signified its efficacy
against Huntington's disease (HD). Nonetheless, its mechanism has not been fully clarified …

Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease

T Zhou, G Zu, X Zhang, X Wang, S Li, X Gong… - …, 2016 - Elsevier
Abstract Ginsenoside Rg1 (Rg1) is a major bioactive ingredient in Panax ginseng that has
low toxicity and has been shown to have neuroprotective effects. The objectives of the …

Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington's disease: Activation of the Nrf2 pathway through lysophosphatidic acid …

M Jang, JH Choi, Y Chang, SJ Lee, SY Nah… - Brain, Behavior, and …, 2019 - Elsevier
Abstract Gintonin (GT), a ginseng-derived lysophosphatidic acid receptor ligand, regulates
various cellular effects and represses inflammation. However, little is known about the …

[HTML][HTML] Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinson's disease

YL Zhang, Y Liu, XP Kang, CY Dou, RG Zhuo… - …, 2018 - Elsevier
Ginsenoside Rb1 has been demonstrated to protect dopaminergic (DA) neurons from death
in vitro. However, the neuroprotective effects and underlying mechanism of Rb1 in treating …