Publisher Summary This chapter reviews the recent advancements in the study of the
transport and metabolism of thyroid hormone. It discusses the role of deiodination …

The major thyroid hormone (TH) secreted by the thyroid gland is thyroxine (T4).
Triiodothyronine (T3), formed chiefly by deiodination of T4, is the active hormone at the …

Thyroxine (T4), the main product of the thyroid gland, is a prohormone that must be activated
by deiodination to triiodothyronine (T) in order to initiate thyroid action. This deiodination …

It is over 40 years since the original demonstration that thyroxine (T4), the principal secretory
product of the thyroid, is deiodinated, to 3, 5, 3'-tri-iodothyronine (T3) in peripheral …

T4 is the main product secreted by the thyroid follicular cells and is regarded as a precursor
of the bioactive hormone T3, most of which is produced by outer ring deiodination of T4 in …

Publisher Summary This chapter explores the metabolic pathways of thyroid hormones. In
vitro studies have been employed to study the nature of this peripheral regulatory …

T HYROIDAL secretion is the only source of thyroxine (T4) in the human systemic circulation,
and in euthyroid man, T4 is the main secretory product of the gland. The metabolic fate of the …

Although it was originally believed that thyroid hormones enter target cells by passive
diffusion, it is now clear that cellular uptake is effected by carrier-mediated processes. Two …

Thyroid hormone is essential for the normal function of virtually all tissues. The
iodothyronine deiodinases catalyze the removal of an iodine residue from the pro-hormone …

Since the discovery of L-thyroxine, the main secretory product of the thyroid gland, and its
major metabolite T3, which exerts the majority of thyroid hormone action via ligand …