Germ cells perform a unique and critical biological function: they propagate the DNA that will
be used to direct development of the next generation. Genetic integrity of germ cell DNA is …

In the complex and dynamic processes of replication, transcription, and translation of DNA
molecules, a large number of replication errors or damage can occur which lead to …

Spermatogenesis is a complex developmental process. During this process, male germ cells
from spermatogonia to sperm cells encounter a number of DNA damages. The most severe …

In male germ cells the repair of DNA double strand breaks (DSBs) differs from that described
for somatic cell lines. Irradiation induced immunofluorescent foci (IRIF's) signifying a double …

Spermatogenesis is a complex process of proliferation and differentiation during male germ
cell development involving mitosis, meiosis and spermiogenesis. Endogenous and …

A major dogma in cancer research is that cancer begins at the cellular level. Because of this
single-cell origin, evolutionary principles have often been used to explain how somatic …

The fundamental underlying paradigm of sexual reproduction is the production of male and
female gametes of sufficient genetic difference and quality that, following syngamy, they …

The acquisition of genotoxin-induced mutations in the mammalian germline is detrimental to
the stable transfer of genomic information. In somatic cells, nucleotide excision repair (NER) …

The maintenance of genomic integrity is of key importance for gametogenesis. Nevertheless,
the processes of DNA replication, mitosis, and meiosis are surprisingly error-prone and …

Male reproductive health has received considerable attention in recent years. In addition to
declining sperm quality, fertility problems and increased incidence of testicular cancer, there …