Generalizing results of randomized trials to clinical practice: reliability and cautions
M Flather, N Delahunty, J Collinson - Clinical trials, 2006 - journals.sagepub.com
Background Well designed randomized controlled trials provide reliable evidence of
treatment effects, but there is no consensus on how best to apply these results to clinical …
treatment effects, but there is no consensus on how best to apply these results to clinical …
Measuring effectiveness: what to expect without a randomized control group
RB D'Agostino, H Kwan - Medical care, 1995 - JSTOR
Randomized controlled trials or studies are often considered the ideal way to evaluate the
effectiveness of a treatment compared to a control. In such a study, the randomization …
effectiveness of a treatment compared to a control. In such a study, the randomization …
Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature
Publication and selection biases in meta-analysis are more likely to affect small studies,
which also tend to be of lower methodological quality. This may lead to “small-study effects,” …
which also tend to be of lower methodological quality. This may lead to “small-study effects,” …
A comparison of observational studies and randomized, controlled trials
K Benson, AJ Hartz - New England Journal of Medicine, 2000 - Mass Medical Soc
Background For many years it has been claimed that observational studies find stronger
treatment effects than randomized, controlled trials. We compared the results of …
treatment effects than randomized, controlled trials. We compared the results of …
Discrepancies between meta-analyses and subsequent large randomized, controlled trials
J LeLorier, G Gregoire, A Benhaddad… - … England Journal of …, 1997 - Mass Medical Soc
Background Meta-analyses are now widely used to provide evidence to support clinical
strategies. However, large randomized, controlled trials are considered the gold standard in …
strategies. However, large randomized, controlled trials are considered the gold standard in …
[引用][C] Considerations for the meta-analysis of randomized clinical trials: summary of a panel discussion
JP Boissel, J Blanchard, E Panak, JC Peyrieux… - Controlled clinical …, 1989 - Elsevier
In therapeutic research meta-analysis is most commonly used to determine more precisely
the beneficial and/or harmful effects of a given treatment from a collection of randomized …
the beneficial and/or harmful effects of a given treatment from a collection of randomized …
Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses
LL Kjaergard, J Villumsen, C Gluud - Annals of internal medicine, 2001 - acpjournals.org
Purpose: To explore whether reported methodologic quality affects estimated intervention
effects in randomized trials and contributes to discrepancies between the results of large …
effects in randomized trials and contributes to discrepancies between the results of large …
Strengths and limitations of meta-analysis: larger studies may be more reliable
Meta-analysis of randomized controlled trials combines information from independent
studies that address a similar question to provide more reliable estimates of treatment …
studies that address a similar question to provide more reliable estimates of treatment …
Reporting and interpretation of randomized clinical trials
H Bauchner, RM Golub, PB Fontanarosa - Jama, 2019 - jamanetwork.com
High-quality randomized clinical trials (RCTs) occupy the highest position on the evidence
pyramid, either as standalone studies or as part of meta-analyses. However, the …
pyramid, either as standalone studies or as part of meta-analyses. However, the …
Where now for meta-analysis?
Figure 1 Distinguished statistician Karl Pearson is seen as the first medical researcher to
use formal techniques to combine data from different studies studies are needed. For …
use formal techniques to combine data from different studies studies are needed. For …