Objective.—To evaluate the results of large clinical trials vs the pooled results of smaller
trials. Data Identification.—Mata-analyses with at least 1" large" study were identified from …

The general methodology, strengths and weaknesses, and political uses of meta-analysis
are examined. As a systematic study of all studies that have been conducted to answer a …

The problem of generalisability in randomised clinical trials was highlighted by studies that
entered only 10-14% of screened patients. To determine the magnitude and source of …

Objectives To assess whether the reported trial characteristics are associated with treatment
effects on all-cause mortality within critical care medicine. Study Design and Setting We …

This chapter has been prepared by the Non-Randomised Studies Methods Group (NRSMG)
of The Cochrane Collaboration (see Box 13.8. a). It is intended to support review authors …

Abstract Background: Randomised controlled trials (RCTs) are commonly viewed as the
best research method to inform public health and social policy. Usually they are thought of …

OBJECTIVES: To assess whether the reported methodological quality of randomized
controlled trials (RCTs) reflects the actual methodological quality and to evaluate the …

Properly planned and conducted randomized clinical trials remain susceptible to a lack of
external validity. The authors illustrate a model-based method to standardize observed trial …

ContextPrevious studies indicate that industry-sponsored trials tend to draw proindustry
conclusions. ObjectiveTo explore whether the association between funding and conclusions …

On the basis of a survey of the methodological literature, we analyze widespread views on
randomization and the advantage of randomized over nonrandomized studies. These views …