Objective To examine whether the association of inadequate or unclear allocation
concealment and lack of blinding with biased estimates of intervention effects varies with the …

OBJECTIVE: To investigate discrepancies between direct comparison and adjusted indirect
comparison in meta-analyses of new versus conventional pharmaceutical interventions …

Meta‐analyses are subject to bias for many of reasons, including publication bias.
Asymmetry in a funnel plot of study size against treatment effect is often used to identify such …

The potential magnitude of publication bias has been examined with a consecutive sample
of published cancer clinical trials. The analysis is based on the premise that the magnitude …

Objective: Heterogeneity between study results can be a problem in any systematic review
or meta-analysis of clinical trials. Identifying its presence, investigating its cause and …

Abstract Background and Objectives In clinical trials, the relative risk or risk ratio (RR) is a
mainstay of reporting of the effect magnitude for an intervention. The RR is the ratio of the …

ContextOngoing efforts to improve the quality of reporting for randomized controlled trials
(RCTs) include the Consolidated Standards of Reporting Trials (CONSORT) statement. We …

My purpose in this talk is to explain why systematic overviews of randomized trials are
needed and to discuss some of the problems involved in conducting such overviews. Two …

In recent years, scientific challenges in the application of randomized trials have become
more apparent, especially with the extension of such trials to the assessment of nondrug …

The random-effects model is often used for meta-analysis of clinical studies. The method
explicitly accounts for the heterogeneity of studies through a statistical parameter …