Hepatoprotective activity of chrysin is mediated through TNF-α in chemically-induced acute liver damage: An in vivo study and molecular modeling

A Hermenean, T Mariasiu… - Experimental and …, 2017 - spandidos-publications.com
Abstract Chrysin (5, 7-dihydroxyflavone) is a naturally occurring flavonoid present at high
levels in honey, propolis and numerous plant extracts. Chrysin is known to have …

A comprehensive review on hepatoprotective and nephroprotective activities of chrysin against various drugs and toxic agents

RB Pingili, AK Pawar, SR Challa, T Kodali… - Chemico-biological …, 2019 - Elsevier
Chrysin belongs to the flavonoids and has been used as traditional medicine from ancient
and has been reported to exhibit a wide range of pharmacological properties. The …

Cyanidin Alleviated CCl4-Induced Acute Liver Injury by Regulating the Nrf2 and NF-κB Signaling Pathways

B Wang, S Cui, B Mao, Q Zhang, F Tian, J Zhao… - Antioxidants, 2022 - mdpi.com
Acute liver injury has multiple causes and can result in liver failure. In this study, we
evaluated the hepatoprotective ability of cyanidin (Cy) and investigated its associated …

Chrysin effect in prevention of acetaminophen-induced hepatotoxicity in rat

A Mohammadi, S Kazemi, M Hosseini… - Chemical Research …, 2019 - ACS Publications
Acetaminophen is a commonly used analgesic drug that induces hepatotoxicity at high
doses and produces the acetaminophen metabolite N-acetyl-p-benzoquinone imine …

Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway

C Balta, H Herman, OM Boldura, I Gasca… - Chemico-biological …, 2015 - Elsevier
We investigated the protective effect of chrysin on chronic liver fibrosis in mice and the
potential mechanism underlying TGF-β1-mediated hepatic stellate cells (HSCs) activation …

Alleviation of hepatic injury by chrysin in cisplatin administered rats: probable role of oxidative and inflammatory markers

MU Rehman, N Ali, S Rashid, T Jain, S Nafees… - Pharmacological …, 2014 - Elsevier
Background Cisplatin is an effective and extensively used chemotherapeutic agent to treat
range of malignancies, but its therapeutic use is limited because of dose-dependent …

Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats

B Varışlı, C Caglayan, FM Kandemir, C Gür… - Molecular Biology …, 2023 - Springer
Background Diclofenac (DF) is a non-steroidal anti-inflammatory drug (NSAID) generally
prescribed for the treatment of pain. In spite of the widespread use of DF, hepatotoxicity has …

Novel antioxidant, deethylated ethoxyquin, protects against carbon tetrachloride induced hepatotoxicity in rats by inhibiting NLRP3 inflammasome activation and …

IY Iskusnykh, ED Kryl'skii, DA Brazhnikova, TN Popova… - Antioxidants, 2021 - mdpi.com
Inflammation and an increase in antioxidant responses mediated by oxidative stress play an
important role in the pathogenesis of acute liver injury (ALI). We utilized in silico prediction of …

[HTML][HTML] Breviscapine ameliorates CCl4‑induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation

Y Liu, PH Wen, XX Zhang, Y Dai… - … journal of molecular …, 2018 - spandidos-publications.com
Acute liver injury is characterized by fibrosis, inflammation and apoptosis, leading to liver
failure, cirrhosis or cancer and affecting the clinical outcome in the long term. However, no …

Quercetin prevents pyrrolizidine alkaloid clivorine-induced liver injury in mice by elevating body defense capacity

L Ji, Y Ma, Z Wang, Z Cai, C Pang, Z Wang - PLoS One, 2014 - journals.plos.org
Quercetin is a plant-derived flavonoid that is widely distributed in nature. The present study
is designed to analyze the underlying mechanism in the protection of quercetin against …