Abstract Carboxylesterases (CESs, EC 3.1. 1.1) constitute a large class of enzymes that
hydrolyze chemicals containing such a functional group as a carboxylic acid ester, amide …

Carboxylesterases (CES, EC 3.1. 1.1) are members of a superfamily of serine hydrolases
that hydrolyze ester, amide, and carbamate bonds. Several different CES genes exist in …

Our understanding of the detailed recognition and processing of clinically useful therapeutic
agents has grown rapidly in recent years, and we are now able to begin to apply this …

The carboxylesterases (CESs) are a family of serine hydrolases that hydrolyze compounds
containing an ester, amide, or thioester. In humans, two dominant forms, CES1 and CES2 …

Carboxylesterases belong to Phase I group of drug metabolizing enzymes. They hydrolyze a
variety of drug esters, amides, carbamates and similar structures. There are five …

Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which …

Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …

The primary functions of carboxylesterases rest in two modes of action–catalytic and
interacting proteins [1–3]. As enzymes, carboxylesterases catalyze both hydrolytic and …

Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Carboxylesterase (CES) is important for detoxification of a wide range of drugs and
xenobiotics and catalyzes cholesterol and fatty acid metabolism. Cynomolgus macaques are …