We tested the hypothesis that chronic testosterone treatment would promote a
cardioprotective phenotype against ischemia/reperfusion (I/R) injury. For this study, 3-month …

This study investigated the impact of testosterone on myocardial ischemia-reperfusion injury
and corresponding intracellular calcium ([Ca2+] i) metabolism. Nonorchiectomized mature …

BACKGROUND: Gender differences exist in the myocardial response to acute
ischemia/reperfusion (I/R) injury and may be attributed to the effects of the sex hormones …

Chronic endogenous testosterone exposure adversely affects proinflammatory and
proapoptotic signaling after ischemia/reperfusion; however, it remains unknown whether a …

Testosterone is an anabolic steroid hormone, which is the major circulating androgen
hormone in males. Testosterone levels decreasing below the normal physiological levels …

Background Although testosterone deficiency is associated with increased risks of heart
disease, the benefits of testosterone therapy are controversial. Moreover, current …

Clinical data suggest an association of increased serum androgens with cardiovascular
mortality in females, but not in males. Therefore, we examined effects of chronic anabolic …

Myocardial ischemia is the leading cause of death in both men and women; however, very
little information exists regarding the effect of testosterone on the response of myocardium to …

Cardiac rupture can be fatal after myocardial infarction (MI). Experiments in animals
revealed gender differences in rupture rate; however, patient data are controversial. We …

The role of testosterone in cardiovascular (CV) homeostasis is in controversy, and the exact
effects of testosterone on the cardiovascular system remain poorly understood. Testosterone …