METHADONE IS A HIGHLY effective synthetic opioid (Food and Drug Administration-
approved in 1947) used primarily in opioid use disorder treatment, but has been studied and …

METHADONE, originally synthesized during World War II as an analgesic substitute for
morphine, is well-known in the world of addiction medicine. 1 Methadone's mechanism of …

Background Postoperative pain is significant in cardiac surgical patients. Perioperative
analgesia with intermittent administration of opioids can result in significant fluctuations in …

Background Inadequately controlled sternotomy pain after cardiac surgery can lead to
delayed recovery and patient suffering. Preoperative intravenous methadone is effective for …

Purpose Inadequate pain control after cardiac surgery increases postoperative morbidity.
Increasing evidence suggests that perioperative intravenous (IV) methadone results in …

Background Opioid analgesia remains a cornerstone of the management of perioperative
pain in cardiac surgical patients. Emerging evidence suggests that intermediate and long …

Objective To investigate the effects of intraoperative methadone in comparison with those of
standard-of-care intraoperative opioids, such as fentanyl and morphine, on pain scores …

Background This retrospective study evaluated the efficacy and safety of intraoperative
methadone compared with short-acting opioids. Methods Patients undergoing cardiac …

Objectives Evaluate the effect of intravenous (IV) methadone versus intrathecal morphine
(ITM) within an Enhanced Recovery After Cardiac Surgery (ERACS) pathway on …

Acute pain is a prevalent issue for patients recovering from surgical procedures. Methadone
has been recognized as a unique option for treatment of surgical pain due to its multiple …