Effect of diesel exhaust particulate (DEP) on immune responses: contributions of particulate versus organic soluble components

PD Siegel, RK Saxena, QB Saxena… - Journal of Toxicology …, 2004 - Taylor & Francis
The effect of diesel exhaust particulate (DEP) exposure on innate, cellular and humoral
pulmonary immunity was studied using high-dose, acute-exposure rat, mouse, and cell …

Effects of diesel exhaust particles (DEP), carbon black, and silica on macrophage responses to lipopolysaccharide: evidence of DEP suppression of macrophage …

HM Yang, MW Barger, V Castranova… - Journal of Toxicology …, 1999 - Taylor & Francis
The effects of diesel exhaust particle (DEP) exposure on alveolar macrophage (AM)
response to ex vivo and in vivo lipopolysaccharide (LPS) challenge were determined by …

Effects of diesel exhaust particles on human alveolar macrophage ability to secrete inflammatory mediators in response to lipopolysaccharide

SD Mundandhara, S Becker, MC Madden - Toxicology in vitro, 2006 - Elsevier
Ambient particulate matter (PM) has been shown to be associated with mortality and
morbidity. Diesel exhaust particles (DEP) contribute to ambient PM. Alveolar macrophages …

The dual effect of the particulate and organic components of diesel exhaust particles on the alteration of pulmonary immune/inflammatory responses and metabolic …

JYC Ma, JKH Ma - Journal of Environmental Science and Health …, 2002 - Taylor & Francis
Exposure to diesel exhaust particles (DEP) is an environmental and occupational health
concern. This review examines the cellular actions of the organic and the particulate …

Components of diesel exhaust particles diversely enhance a variety of respiratory diseases related to infection or allergy: extracted organic chemicals and the residual …

H Takano, R Yanagisawa, K Inoue - Journal of Clinical Biochemistry …, 2007 - jstage.jst.go.jp
Experimental and epidemiological studies have reported that diesel exhaust particles (DEP)
can aggravate a variety of respiratory diseases including infection or allergy. However, the …

Suppression of phagocytic and bactericidal functions of rat alveolar macrophages by the organic component of diesel exhaust particles

XJ Yin, CC Dong, JYC Ma, JR Roberts… - Journal of Toxicology …, 2007 - Taylor & Francis
Exposure to diesel exhaust particles (DEP) was shown to increase the susceptibility of the
lung to bacterial infection in rats. In this study, the effects of DEP on alveolar macrophage …

Differential potentiation of allergic lung disease in mice exposed to chemically distinct diesel samples

T Stevens, SH Cho, WP Linak… - Toxicological …, 2009 - academic.oup.com
Numerous studies have demonstrated that diesel exhaust particles (DEP) potentiate allergic
immune responses, however the chemical components associated with this effect, and the …

Pulmonary exposure to diesel exhaust particles induces airway inflammation and cytokine expression in NC/Nga mice

K Inoue, H Takano, R Yanagisawa, T Ichinose… - Archives of …, 2005 - Springer
Although several studies have reported that diesel exhaust particles (DEP) affect
cardiorespiratory health in animals and humans, the effect of DEP on animal models with …

Organic compounds from diesel exhaust particles elicit a proinflammatory response in human airway epithelial cells and induce cytochrome p450 1A1 expression

V Bonvallot, A Baeza-Squiban, A Baulig… - American journal of …, 2001 - atsjournals.org
Diesel exhaust particles (DEP) are known to enhance inflammatory responses in human
volunteers. In cultured human bronchial epithelial (16HBE) cells, they induce the release of …

Susceptibility of inflamed alveolar and airway epithelial cells to injury induced by diesel exhaust particles of varying organic carbon content

ND Manzo, R Slade, JH Richards… - Journal of Toxicology …, 2010 - Taylor & Francis
Exposure to traffic-related ambient air pollution, such as diesel exhaust particles (DEP), is
associated with adverse health outcomes, especially in individuals with preexisting …