Unique opioid mimetic substances containing identical N-terminal aromatic residues
separated by an unbranched alkyl chain containing two to eight methylene groups were …

The concept of “ligand bias” at G protein coupled receptors has been introduced to describe
ligands which preferentially stimulate one intracellular signaling pathway over another …

Endomorphin-2 (H-Tyr-Pro-Phe-Phe-NH2) and [Dmt1] EM-2 (Dmt= 2 ', 6 '-dimethyl-l-
tyrosine) analogues, containing alkylated Phe3 derivatives, 2 '-monomethyl (2, 2 '), 3 ', 5 ' …

Gene targeting was used to delete exon 2 of mouse DOR-1, which encodes the δ opioid
receptor. Essentially all 3H-[D-Pen 2, D-Pen 5] enkephalin (3 H-DPDPE) and 3H-[D-Ala 2, D …

Structural, stereochemical, stereoelectronic and conformational requirements for biological
activity of dynorphin A1–11‐NH2 analogues at opioid receptors were explored by …

The dopamine D3 receptor has been recognized to play an important role in the molecular
mechanisms of various neuropsychiatric disorders. The development of new dopamine D3 …

μ-Opioid analgesics are a mainstay in the treatment of acute and chronic pain of multiple
origins, but their side effects, such as constipation, respiratory depression, and abuse …

Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …

Four different oploid receptor binding assays and three different isolated tissue studies were
used to screen for delta receptor-selective nonpeptidic compounds.(ą-((a-R5)-a-((2S5, 5R5) …

In order to study the structure-activity relationships of dynorphin A-(1-8) amide [Dyn (l-8)-
NH2], 20 analogues were synthesized by the solution method. Their biological activities …