Background Cuff and spared nerve injury (SNI) in the sciatic territory are widely used to
model neuropathic pain. Because nociceptive information is first detected in skin, it is …

Neuropathic pain is a debilitating form of treatment resistant chronic pain and responds
poorly to the clinically available therapies. Studies from animal models of neuropathic pain …

The chronic constriction injury (CCI) of the sciatic nerve is a nerve injury‐based model of
neuropathic pain (NP). Comorbidities of NP such as depression, anxiety, and cognitive …

The generation of knock-out and transgenic mice offers a promising approach to the
identification of novel biochemical factors that contribute to persistent pain conditions. To …

Peripheral neuropathic pain is the most debilitating of all clinical pain syndromes and affects
a large and growing number of people worldwide. There are diverse causes for peripheral …

Polyethylene cuffs of varying inner diameters were applied to the rat sciatic or sural nerve
with the aim of inducing a standardized nerve injury, as assessed by morphometric analyses …

The spared nerve injury (SNI) model mimics human neuropathic pain related to peripheral
nerve injury and is based upon an invasive but simple surgical procedure. Since its first …

ABSTRACT BACKGROUND AND OBJECTIVES: Ideal models should reproduce just
sensory deficits, such as alodynia, hyperalgesia and spontaneous pain for short periods …

Neuropathic pain refers to pain that originates from pathology of the nervous system.
Diabetes, infection (herpes zoster), nerve compression, nerve trauma, and autoimmune …

Neurosensory disorders such as pain and pruritus remain a major health problem greatly
impacting the quality of life, and often increasing the risk of mortality. Current pre-clinical …