Update on paroxysmal nocturnal haemoglobinuria: on the long way to understand the principles of the disease

J Schubert, A Röth - European Journal of Haematology, 2015 - Wiley Online Library
The understanding of the clinical manifestations in paroxysmal nocturnal haemoglobinuria
(PNH) has made great progress. The main symptoms of this disease such as abdominal …

Paroxysmal nocturnal haemoglobinuria

A Hill, AE DeZern, T Kinoshita… - Nature reviews Disease …, 2017 - nature.com
Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic stem cell (HSC)
disease that presents with haemolytic anaemia, thrombosis and smooth muscle dystonias …

Paroxysmal nocturnal hemoglobinuria: pathophysiology, natural history and treatment options in the era of biological agents

AM Risitano, B Rotoli - Biologics: Targets and Therapy, 2008 - Taylor & Francis
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal non-malignant hematological
disease characterized by the expansion of hematopoietic stem cells (HSCs) and progeny …

The cellular pathogenesis of paroxysmal nocturnal haemoglobinuria

A Karadimitris, L Luzzatto - Leukemia, 2001 - nature.com
Paroxysmal nocturnal haemoglobinuria (PNH) is a unique disorder characterised by the
triad of intravascular haemolysis, thrombosis and bone marrow failure. In the early seventies …

Management of paroxysmal nocturnal haemoglobinuria: a personal view

L Luzzatto, G Gianfaldoni… - British journal of …, 2011 - Wiley Online Library
Paroxysmal nocturnal haemoglobinuria (PNH) is a serious form of acquired haemolytic
anaemia with several features that make it unique, including the fact that it is caused by …

Pathogenesis and management of paroxysmal nocturnal haemoglobinuria

CH Packman - Blood reviews, 1998 - Elsevier
Over the past 30 years, our understanding of the pathogenesis of paroxysmal nocturnal
haemoglobinuria (PNH) has increased dramatically. During that time, the events during …

The dual pathogenesis of paroxysmal nocturnal hemoglobinuria

L Luzzatto, M Bessler - Current Opinion in Hematology, 1996 - journals.lww.com
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired blood disease with distinct and
rather peculiar characteristics that have puzzled hematologists for more than a century. PNH …

Recent advances in the diagnosis, monitoring, and management of patients with paroxysmal nocturnal hemoglobinuria

SJ Richards, A Hill, P Hillmen - Cytometry Part B: Clinical …, 2007 - Wiley Online Library
Until recently, there has been no specific therapy for PNH with clinical management mainly
supportive in terms of cytopenias and control of thrombotic risk. Currently, the only curative …

[HTML][HTML] Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

L Luzzatto - F1000Research, 2016 - ncbi.nlm.nih.gov
Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disease that has been
investigated for over one century and has revealed unique aspects of the pathogenesis and …

How we treat paroxysmal nocturnal hemoglobinuria: a consensus statement of the Canadian PNH Network and review of the national registry

CJ Patriquin, T Kiss, S Caplan… - European Journal of …, 2019 - Wiley Online Library
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disease characterized by
intravascular hemolysis, thrombophilia, and marrow failure. Its phenotype is due to absent or …