BCR-ABL1 plays a key role in the pathogenesis of chronic myeloid leukemia (CML), and it
has been investigated as a druggable target of tyrosine kinase inhibitors (TKIs) over two …

Chronic myeloid leukemia (CML), caused by constitutively active BCR-ABL1 fusion tyrosine
kinase, has served as a paradigm for successful application of molecularly targeted cancer …

Background Malignant stem cells have been identified in acute myelogenous leukemia,
chronic myeloid leukemia, and some types of acute lymphoblastic leukemia. Like normal …

Nowadays, more than 90% of patients affected by chronic myeloid leukemia (CML) survive
with a good quality of life, thanks to the clinical efficacy of tyrosine kinase inhibitors (TKIs) …

The genetic programs that promote retention of self-renewing leukemia stem cells (LSCs) at
the apex of cellular hierarchies in acute myeloid leukemia (AML) are not known. In a mouse …

Acute myeloid leukemia (AML) is one of the most common types of leukemia in adults. While
complete remission can be obtained with intensive chemotherapy in young and fit patients …

Stem cells are an integral component of normal mammalian physiology and have been
intensively studied in many systems. Intriguingly, substantial evidence indicates that stem …

Human acute myeloid leukemia (AML) originates from rare leukemia stem cells (LSCs).
Because these chemotherapy-resistant LSCs are thought to underlie disease relapse …

Hematopoietic stem cells (HSC) are responsible for the production of mature blood cells. To
ensure that the HSC pool does not get exhausted over the lifetime of an individual, most …

Many cancers seem to depend on a small population of'cancer stem cells' for their continued
growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be …