[PDF][PDF] Mitochondrial fission factor Drp1 maintains oocyte quality via dynamic rearrangement of multiple organelles

O Udagawa, T Ishihara, M Maeda, Y Matsunaga… - Current Biology, 2014 - cell.com
Mitochondria are dynamic organelles that change their morphology by active fusion and
fission in response to cellular signaling and differentiation [1, 2]. The in vivo role of …

Mitochondrial dynamics controlled by mitofusins define organelle positioning and movement during mouse oocyte maturation

T Wakai, Y Harada, K Miyado… - Molecular human …, 2014 - academic.oup.com
Mitochondria are abundant in fully grown mammalian oocytes with a unique spherical
morphology, but the mechanisms controlling mitochondria behavior are not well understood …

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

N Ishihara, M Nomura, A Jofuku, H Kato, SO Suzuki… - Nature cell …, 2009 - nature.com
Mitochondrial morphology is dynamically controlled by a balance between fusion and
fission. The physiological importance of mitochondrial fission in vertebrates is less clearly …

[HTML][HTML] New insights into the function and regulation of mitochondrial fission

H Otera, N Ishihara, K Mihara - … et Biophysica Acta (BBA)-Molecular Cell …, 2013 - Elsevier
Mitochondrial morphology changes dynamically by coordinated fusion and fission and
cytoskeleton-based transport. Cycles of outer and inner membrane fusion and fission are …

Emerging functions of mammalian mitochondrial fusion and fission

H Chen, DC Chan - Human molecular genetics, 2005 - academic.oup.com
Mitochondria provide a myriad of services to the cell, including energy production, calcium
buffering and regulation of apoptosis. How these diverse functions are coordinated among …

Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress

W Qian, S Choi, GA Gibson, SC Watkins… - Journal of cell …, 2012 - journals.biologists.com
Mitochondrial fission and fusion cycles are integrated with cell cycle progression. In this
paper, we demonstrate that the inhibition of mitochondrial fission protein Drp1 causes an …

Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss

O Amartuvshin, CH Lin, SC Hsu, SH Kao, A Chen… - Aging cell, 2020 - Wiley Online Library
Abstract Changes in mitochondrial dynamics (fusion and fission) are known to occur during
stem cell differentiation; however, the role of this phenomenon in tissue aging remains …

Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal …

T Ishihara, R Ban-Ishihara, M Maeda… - … and cellular biology, 2015 - Taylor & Francis
Mitochondria are dynamic organelles, and their fusion and fission regulate cellular
signaling, development, and mitochondrial homeostasis, including mitochondrial DNA …

[HTML][HTML] Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila …

R Sênos Demarco, DL Jones - Scientific reports, 2019 - nature.com
Mitochondria are essential organelles that have recently emerged as hubs for several
metabolic and signaling pathways in the cell. Mitochondrial morphology is regulated by …

[HTML][HTML] Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA

PA Parone, S Da Cruz, D Tondera, Y Mattenberger… - PloS one, 2008 - journals.plos.org
Mitochondria form a highly dynamic tubular network, the morphology of which is regulated
by frequent fission and fusion events. However, the role of mitochondrial fission in …