The purpose of this study was to investigate the in vivo distribution and antitumor activity of
irinotecan (camptothecin (CPT)-11)-loaded folate-targeted liposome (F-Lip) in tumor-bearing …

Instability of targeting ligand is a roadblock towards successful development of folate
targeted liposomes. Folate ligands have been linked to polyethylene glycol (PEG) and …

Background The folate receptor (FR) is amplified in a wide variety of human tumors. Thus,
targeting cytotoxic therapies to FR is a promising strategy for chemotherapy. Materials and …

Purpose Using different chain lengths of PEG as linkers to develop a novel folate (FA) and
TAT peptide co-modified doxorubicin (DOX)-loaded liposome (FA/TAT-LP-DOX) and …

Abstract Preclinical Research The expression of the folate receptor (FR) is amplified in many
cancer types. Oridonin (ORI, C20H28O6) is an isolate from R abdosia rubescens (H emsl.) H …

Liposomes have been well used as an efficient delivery system for cancer therapy.
Overexpressed folate receptor is a confirmed tumor-associated antigen that binds folate and …

Cancer cells reflect higher level of ROS in comparison to the normal cell, so they become
more vulnerable to further oxidative stress induced by exogenous ROS-generating agents …

Introduction Ligand-conjugated liposomes are promising for the treatment of specific
receptor-overexpressing cancers. However, previous studies have shown inconsistent …

Targeted drug delivery has the potential to improve the efficacy of a therapeutic agent while
reducing its side effects. The folate receptor type β (FR-β) is a cell surface marker selectively …

Targeting of liposomes with phospholipid-anchored folate conjugates is an attractive
approach to deliver chemotherapeutic agents to folate receptor (FR) expressing tumors. The …