Background: Clinical studies show that the most common single-point mutation in humans,
ALDH2 (aldehyde dehydrogenase 2) rs671 mutation, is a risk factor for the development and …

Previous evidence has indicated a beneficial role for aldehyde dehydrogenase 2 (ALDH2)
in suppressing atherosclerotic plaque progression and instability. However, the underlying …

Previous studies demonstrated that aldehyde dehydrogenase 2 (ALDH2) rs671
polymorphism, which eliminates ALDH2 activity down to 1%-6%, is a susceptibility gene for …

Acetaldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme detoxifying
acetaldehyde and endogenous lipid aldehydes; previous studies suggest a protective role of …

Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …

Atherosclerosis is the most common cause of cardiovascular diseases worldwide. The
endothelial cell apoptosis elicited by oxidized low-density lipoprotein (ox-LDL), which …

Foam cell formation plays an important role in the initiation and progression of
atherosclerosis. Aldehyde dehydrogenase 2 (ALDH2), a key enzyme for aldehyde …

Macrophages are key immune cells found in atherosclerotic plaques and critically shape
atherosclerotic disease development. Targeting the functional repertoire of macrophages …

Abstract Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is an enzyme that detoxifies
aldehydes by converting them to carboxylic acids. ALDH2 deficiency is known to increase …

Abstract Background and Aims The Glu504Lys polymorphism in the aldehyde
dehydrogenase 2 (ALDH2) gene is closely associated with myocardial …