Abstract Histone deacetylase 11 (HDAC11), a sole member of the class IV HDAC subfamily,
participates in various cardiovascular diseases. Recent evidence showed that pyroptosis …

Nearly 8% of the human population carries an inactivating point mutation in the gene that
encodes the cardioprotective enzyme aldehyde dehydrogenase 2 (ALDH2). This genetic …

ABCA1 and ABCG1 expression, as well as cholesterol efflux to apolipoprotein A1 (ABCA1-
dependent) and high-density lipoprotein. Using chromatin immunoprecipitation followed by …

Abstract Aldehyde dehydrogenase 2 (ALDH2) is a key mitochondrial enzyme in the
metabolism of aldehydes and may have beneficial cardiovascular effects for conditions such …

The endothelial dysfunction induced by oxidized low‐density lipoprotein (ox‐LDL) plays an
important role in the pathogenesis of atherosclerosis, which can lead to oxidative stress and …

Necroptosis is one of a regulated programmed death mode, fibrosis is closely related with
cell death. It has been reported that inhibition of necroptosis can play the protective role in …

Cardiovascular disease (CVD) is the leading cause of mortality in the world, with most CVD-
related deaths resulting from myocardial infarction or stroke. The main underlying cause of …

HDL cholesterol (HDL-C) plasma levels are inversely related to cardiovascular disease risk.
Previous studies have shown in animals and humans that HDL promotes regression of …

Abstract Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is the major enzyme
responsible for metabolizing toxic acetaldehyde to acetate and acts as a protective or …

Endothelial-mesenchymal transition (EndMT) is associated with various cardiovascular
diseases and in particular with atherosclerosis and plaque instability. However, the …