Objective: Antibody blockade of the “do not eat me” signal CD47 (cluster of differentiation
47) enhances efferocytosis and reduces lesion size and necrotic core formation in murine …

Emerging evidence strongly supports a role for HDAC2 in the transcriptional regulation of
endothelial genes and vascular function. We have recently demonstrated that HDAC2 …

Innate mesenchymal stem cells exhibiting multilineage differentiation and tissue (re)
generative—or pathogenic—properties reside in perivascular niches. Subsets of these …

Rationale: Reduced plasma cholesterol and increased high-density lipoprotein (HDL) levels
promote regression of atherosclerosis, in a process characterized by lipid unloading and …

Microvascular barrier dysfunction is the central pathophysiological feature of acute lung
injury (ALI). RAB26 is a newly identified small GTPase involved in the regulation of …

Background: Metabolic alterations provide substrates that influence chromatin structure to
regulate gene expression that determines cell function in health and disease. Heightened …

Introduction Neutrophils are critical for host immune defense; yet, aberrant neutrophil tissue
infiltration triggers tissue damage. Neutrophils are heterogeneous functionally, and adopt …

Review on how dangerous atherosclerotic plaques form and the critical role for defective
phagocytic clearance (or “efferocytosis”) of apoptotic macrophages in these lesions …

Advanced glycated end-product receptor 1 (AGER1) protects against vascular disease
promoted by oxidants, such as advanced glycated end products (AGEs), via inhibition of …

Melanoma and non-small-cell lung carcinoma (NSCLC) cell lines are characterized by an
intrinsic population of cancer stem-like cells (CSC), and high expression of detoxifying …