Oxidative stress is implicated as an important molecular mechanism underlying fibrosis in a
variety of organs, including the lungs. However, the causal role of reactive oxygen species …

Oxidative stress has been linked to various disease states as well as physiological aging.
The lungs are uniquely exposed to a highly oxidizing environment and have evolved several …

Pulmonary fibrosis can be observed as an end state in a number of chronic inflammatory
pulmonary diseases. Although the mechanisms by which lung fibrosis develops are not fully …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disorder in which excessive
deposition of extracellular matrix leads to irreversible scarring of interstitial lung tissue. The …

Idiopathic pulmonary fibrosis is characterised by abnormal reepithelialisation and
remodelling consequent to persistent stimuli or injury. The involvement of oxidative stress in …

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by
progressive fibrosis of the alveolar interstitium. The pathogenesis is thought to involve …

Endoplasmic reticulum (ER) stress is associated with development and progression of
fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). ER stress was first implicated …

Pulmonary fibrosis is a relatively rare but devastating disease characterized by the
excessive deposition of extracellular matrix. The increased matrix results in reduced lung …

While the factors that regulate the onset and progression of idiopathic pulmonary fibrosis
(IPF) are incompletely understood, recent investigations have revealed that endoplasmic …

TGF-β signaling is required for normal tissue repair; however, excessive TGF-β signaling
can lead to robust profibrotic gene expression in fibroblasts, resulting in tissue fibrosis. TGF …