While small Maf proteins have been suggested to be essential for the Nrf2-mediated
activation of antioxidant response element (ARE)-dependent genes, the extent of their …

Nrf2 accumulates in nuclei upon exposure to oxidative stress, heterodimerizes with a small
Maf protein, and activates the transcription of stress target genes through antioxidant …

The antioxidant response element (ARE) is known to regulate expression and induction of
NQO1, GST Ya, and other detoxifying enzyme genes in response to antioxidants and …

The antioxidant response element (ARE) mediates the transcriptional activation of many
genes encoding phase II drug-metabolizing enzymes in response to oxidative stress. Recent …

Antioxidant-response element (ARE) and nuclear factor Nrf2-mediated expression and
coordinated induction of genes encoding chemopreventive proteins, including NQO1, are …

Oxidative stress plays an important part in the pathogenesis of a variety of diseases. The
ability to mount an efficient response against the continuous threat posed by exogenous and …

Nrf1 is a member of the CNC-basic leucine zipper (CNC-bZIP) family of transcription factors.
CNC bZIP factors, together with small Maf proteins, bind as heterodimers to the NF-E2/AP-1 …

Embryogenesis is a period during which cells are exposed to dynamic changes of various
intracellular and extracellular stresses. Oxidative stress response genes are regulated by …

Transcriptional activation of genes that play a role in detoxification of xenobiotics and
defense against oxidative stress is mediated in part by the antioxidant response element …

Nrf2-small Maf heterodimer activates the transcription of many cytoprotective genes through
the antioxidant response element and serves as a key factor in xenobiotic and oxidative …