Oxidative stress-responsive transcription is regulated in part through cis-active sequences
known as antioxidant response elements (ARE). Activation through the ARE involves …

The small Maf basic leucine zipper (bZIP) proteins MafF, MafG and MafK, while modest in
size, have emerged as crucial regulators of mammalian gene expression. Intriguingly, small …

Antioxidant response element (ARE)-mediated expression and coordinated induction of
antioxidant enzymes is a critical mechanism of protection against chemically induced …

The ubiquitous toxic metalloid arsenic elicits pleiotropic adverse and adaptive responses in
mammalian species. The biological targets of arsenic are largely unknown at present. We …

A central mechanism in cellular defence against oxidative or electrophilic stress is mediated
by transcriptional induction of genes via the ARE (antioxidant-response element), a cis …

Abstract Nrf2-small Maf (sMaf) heterodimer is essential for the inducible expression of
cytoprotective genes upon exposure to oxidative and xenobiotic stresses. While the Nrf2 …

Nrf2, a basic leucine zipper transcription factor, is an essential activator of the coordinated
transcription of genes encoding antioxidant enzymes and phase II detoxifying enzymes …

To maintain intracellular redox homeostasis, genes encoding many antioxidants and
detoxification enzymes are transcriptionally upregulated upon deleterious oxidative stress …

The antioxidant responsive element (ARE) is a cis-acting regulatory element of genes
encoding phase II detoxification enzymes and antioxidant proteins, such as NAD (P) H …

Background Nrf2 belongs to the Cap‐N‐Collar (CNC) transcription factor family and is
essential for the antioxidant responsive element (ARE)‐mediated expression of a group of …