Although DNA modifications play an important role in gene regulation, the underlying
mechanisms remain elusive. We developed EpiSELEX-seq to probe the sensitivity of …

DNA methylation, especially CpG methylation at promoter regions, has been generally
considered as a potent epigenetic modification that prohibits transcription factor (TF) …

Methylation of CpG (cytosine-phosphate-guanine) dinucleotides is a common epigenetic
mark that influences gene expression. The effects of methylation on transcription factor (TF) …

Epigenetic DNA modification impacts gene expression, but the underlying molecular
mechanisms are only partly understood. Adding a methyl group to a cytosine base locally …

Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic
repressor of transcription. Because DNA methylation is reversible, there is much interest in …

Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

DNA methylation is an epigenetic modification that is generally associated with repression of
transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent …

Background DNA methylation in promoters is closely linked to downstream gene repression.
However, whether DNA methylation is a cause or a consequence of gene repression …