Despa and Vigmond Whole-Heart Electrophysiology and Modeling 185 conclusion was
supported by the observation that slowing down the rate of Phase-1 repolarization by …

Computational modeling of cardiac cellular electrophysiology has a long history, and many
models are now available for different species, cell types, and experimental preparations …

Mathematical models of the electrical activity of the heart using equations for protein ion
channels and other transporters began with the Noble 1962 model. These models then …

Mathematical models of the electrophysiology of cardiac cells have advanced considerably
since the first model described by four differential equations published in the 1960s (Noble …

We present a review of the cardiac ventricular cell electrophysiology models developed by
Prof. Denis Noble and colleagues as an example of how models may be published using a …

This paper summarizes the advances made by the DiFrancesco and Noble (DFN) model of
cardiac cellular electrophysiology, which was published in Philosophical Transactions B in …

The local control theory of excitation-contraction (EC) coupling in cardiac muscle asserts that
L-type Ca 2+ current tightly controls Ca 2+ release from the sarcoplasmic reticulum (SR) via …

In this article, we briefly describe how transmembrane currents and other cellular ionic
processes are modeled to produce action potentials. Then we discuss 45 models of cardiac …

The modelling of the electrophysiology of cardiac cells is one of the most mature areas of
systems biology. This extended concentration of research effort brings with it new …

Mathematical models of cardiac cellular electrophysiology have evolved significantly over
the last 50 years. Beginning with the initial four ODE models from Noble in 1962, models are …